2ega

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{{Seed}}
 
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[[Image:2ega.png|left|200px]]
 
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==Solution structure of the first SH3 domain from human KIAA0418 protein==
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The line below this paragraph, containing "STRUCTURE_2ega", creates the "Structure Box" on the page.
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<StructureSection load='2ega' size='340' side='right'caption='[[2ega]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2ega]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EGA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EGA FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ega FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ega OCA], [https://pdbe.org/2ega PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ega RCSB], [https://www.ebi.ac.uk/pdbsum/2ega PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ega ProSAT], [https://www.topsan.org/Proteins/RSGI/2ega TOPSAN]</span></td></tr>
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{{STRUCTURE_2ega| PDB=2ega | SCENE= }}
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</table>
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== Function ==
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===Solution structure of the first SH3 domain from human KIAA0418 protein===
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[https://www.uniprot.org/uniprot/SPD2A_HUMAN SPD2A_HUMAN] Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide.<ref>PMID:12615925</ref> <ref>PMID:15710328</ref> <ref>PMID:15710903</ref> <ref>PMID:19755710</ref> <ref>PMID:20609497</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
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Check<jmol>
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2EGA is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EGA OCA].
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eg/2ega_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ega ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Hayashi, F.]]
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[[Category: Large Structures]]
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[[Category: Inoue, K.]]
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[[Category: Hayashi F]]
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[[Category: Kurosaki, C.]]
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[[Category: Inoue K]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Kurosaki C]]
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[[Category: Yokoyama, S.]]
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[[Category: Yokoyama S]]
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[[Category: Yoshida, M.]]
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[[Category: Yoshida M]]
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[[Category: Kiaa0418 protein]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Sh3 domain]]
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[[Category: Sh3 multiple domains 1]]
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[[Category: Sh3md1]]
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[[Category: Signaling protein]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 15:04:41 2008''
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Current revision

Solution structure of the first SH3 domain from human KIAA0418 protein

PDB ID 2ega

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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