2iq1

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{{Seed}}
 
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[[Image:2iq1.png|left|200px]]
 
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==Crystal structure of human PPM1K==
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The line below this paragraph, containing "STRUCTURE_2iq1", creates the "Structure Box" on the page.
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<StructureSection load='2iq1' size='340' side='right'caption='[[2iq1]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2iq1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IQ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IQ1 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_2iq1| PDB=2iq1 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iq1 OCA], [https://pdbe.org/2iq1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iq1 RCSB], [https://www.ebi.ac.uk/pdbsum/2iq1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iq1 ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2iq1 TOPSAN]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/PPM1K_HUMAN PPM1K_HUMAN] Intermediate maple syrup urine disease.
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== Function ==
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[https://www.uniprot.org/uniprot/PPM1K_HUMAN PPM1K_HUMAN] Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development.<ref>PMID:17374715</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iq/2iq1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2iq1 ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of human PPM1K===
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==See Also==
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*[[Protein phosphatase 3D structures|Protein phosphatase 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_18058037}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 18058037 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_18058037}}
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==About this Structure==
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2IQ1 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IQ1 OCA].
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==Reference==
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Structural genomics of protein phosphatases., Almo SC, Bonanno JB, Sauder JM, Emtage S, Dilorenzo TP, Malashkevich V, Wasserman SR, Swaminathan S, Eswaramoorthy S, Agarwal R, Kumaran D, Madegowda M, Ragumani S, Patskovsky Y, Alvarado J, Ramagopal UA, Faber-Barata J, Chance MR, Sali A, Fiser A, Zhang ZY, Lawrence DS, Burley SK, J Struct Funct Genomics. 2007 Sep;8(2-3):121-40. Epub 2007 Dec 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18058037 18058037]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Adams, J.]]
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[[Category: Large Structures]]
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[[Category: Almo, S C.]]
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[[Category: Adams J]]
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[[Category: Bain, K T.]]
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[[Category: Almo SC]]
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[[Category: Bonanno, J B.]]
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[[Category: Bain KT]]
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[[Category: Burley, S K.]]
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[[Category: Bonanno JB]]
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[[Category: Freeman, J.]]
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[[Category: Burley SK]]
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[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
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[[Category: Freeman J]]
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[[Category: Pelletier, L.]]
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[[Category: Pelletier L]]
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[[Category: Russell, M.]]
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[[Category: Russell M]]
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[[Category: Sauder, J M.]]
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[[Category: Sauder JM]]
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[[Category: Wasserman, S.]]
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[[Category: Wasserman S]]
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[[Category: Hydrolase]]
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[[Category: New york structural genomix research consortium]]
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[[Category: Nysgxrc]]
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[[Category: Protein phosphatase 2c kappa]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-2]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 15:14:03 2008''
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Current revision

Crystal structure of human PPM1K

PDB ID 2iq1

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