1u5d

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(New page: 200px<br /><applet load="1u5d" size="450" color="white" frame="true" align="right" spinBox="true" caption="1u5d, resolution 1.7&Aring;" /> '''Crystal Structure of ...)
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[[Image:1u5d.gif|left|200px]]<br /><applet load="1u5d" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1u5d, resolution 1.7&Aring;" />
 
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'''Crystal Structure of the PH domain of SKAP55'''<br />
 
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==About this Structure==
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==Crystal Structure of the PH domain of SKAP55==
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1U5D is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1U5D OCA].
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<StructureSection load='1u5d' size='340' side='right'caption='[[1u5d]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1u5d]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U5D FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5d OCA], [https://pdbe.org/1u5d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u5d RCSB], [https://www.ebi.ac.uk/pdbsum/1u5d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u5d ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SKAP1_HUMAN SKAP1_HUMAN] Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells.<ref>PMID:10856234</ref> <ref>PMID:11909961</ref> <ref>PMID:12652296</ref> <ref>PMID:15939789</ref> <ref>PMID:16980616</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u5/1u5d_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u5d ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Eck, M.J.]]
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[[Category: Eck MJ]]
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[[Category: Neel, B.G.]]
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[[Category: Neel BG]]
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[[Category: Swanson, K.D.]]
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[[Category: Swanson KD]]
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[[Category: Tang, Y.]]
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[[Category: Tang Y]]
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[[Category: SO4]]
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[[Category: ph domain]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 03:51:12 2007''
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Current revision

Crystal Structure of the PH domain of SKAP55

PDB ID 1u5d

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