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1npy

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{{Seed}}
 
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[[Image:1npy.png|left|200px]]
 
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<!--
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==Structure of shikimate 5-dehydrogenase-like protein HI0607==
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The line below this paragraph, containing "STRUCTURE_1npy", creates the "Structure Box" on the page.
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<StructureSection load='1npy' size='340' side='right'caption='[[1npy]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1npy]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NPY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NPY FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
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{{STRUCTURE_1npy| PDB=1npy | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1npy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1npy OCA], [https://pdbe.org/1npy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1npy RCSB], [https://www.ebi.ac.uk/pdbsum/1npy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1npy ProSAT], [https://www.topsan.org/Proteins/MCSG/1npy TOPSAN]</span></td></tr>
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</table>
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===Structure of shikimate 5-dehydrogenase-like protein HI0607===
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== Function ==
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[https://www.uniprot.org/uniprot/SHDHL_HAEIN SHDHL_HAEIN] In vitro, is able to catalyze the NADP(+)-dependent oxidation of shikimate to 3-dehydroshikimate. However, has much lower activity than classical shikimate dehydrogenases AroE, indicating that shikimate may not be the biological substrate. Cannot utilize NAD(+) instead of NADP(+). Is not able to catalyze the oxidation of quinate.<ref>PMID:15735308</ref>
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== Evolutionary Conservation ==
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<!--
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_15735308}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 15735308 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/np/1npy_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_15735308}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1NPY is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NPY OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1npy ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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Crystal structure of a novel shikimate dehydrogenase from Haemophilus influenzae., Singh S, Korolev S, Koroleva O, Zarembinski T, Collart F, Joachimiak A, Christendat D, J Biol Chem. 2005 Apr 29;280(17):17101-8. Epub 2005 Feb 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15735308 15735308]
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<references/>
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__TOC__
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</StructureSection>
[[Category: Haemophilus influenzae]]
[[Category: Haemophilus influenzae]]
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[[Category: Collart, F.]]
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[[Category: Large Structures]]
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[[Category: Joachimiak, A.]]
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[[Category: Collart F]]
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[[Category: Korolev, S.]]
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[[Category: Joachimiak A]]
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[[Category: Koroleva, O.]]
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[[Category: Korolev S]]
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[[Category: MCSG, Midwest Center for Structural Genomics.]]
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[[Category: Koroleva O]]
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[[Category: Zarembinski, T.]]
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[[Category: Zarembinski T]]
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[[Category: Mcsg]]
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[[Category: Midwest center for structural genomic]]
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[[Category: Protein structure initiative]]
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[[Category: Psi]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 15:50:10 2008''
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Current revision

Structure of shikimate 5-dehydrogenase-like protein HI0607

PDB ID 1npy

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