1ucv

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{{Seed}}
 
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[[Image:1ucv.png|left|200px]]
 
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==Sterile alpha motif (SAM) domain of ephrin type-A receptor 8==
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The line below this paragraph, containing "STRUCTURE_1ucv", creates the "Structure Box" on the page.
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<StructureSection load='1ucv' size='340' side='right'caption='[[1ucv]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ucv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UCV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UCV FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ucv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ucv OCA], [https://pdbe.org/1ucv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ucv RCSB], [https://www.ebi.ac.uk/pdbsum/1ucv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ucv ProSAT], [https://www.topsan.org/Proteins/RSGI/1ucv TOPSAN]</span></td></tr>
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{{STRUCTURE_1ucv| PDB=1ucv | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/EPHA8_HUMAN EPHA8_HUMAN] Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uc/1ucv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ucv ConSurf].
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<div style="clear:both"></div>
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===Sterile alpha motif (SAM) domain of ephrin type-A receptor 8===
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==See Also==
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*[[Ephrin receptor 3D structures|Ephrin receptor 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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1UCV is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UCV OCA].
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Transferase]]
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[[Category: Large Structures]]
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[[Category: Goroncy, A.]]
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[[Category: Goroncy A]]
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[[Category: Inoue, M.]]
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[[Category: Inoue M]]
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[[Category: Kigawa, T.]]
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[[Category: Kigawa T]]
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[[Category: Kobayashi, N.]]
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[[Category: Kobayashi N]]
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[[Category: Koshiba, S.]]
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[[Category: Koshiba S]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Tochio N]]
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[[Category: Tochio, N.]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S.]]
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[[Category: Developmental regulation]]
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[[Category: Receptor oligomerization]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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[[Category: Tyrosine kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 15:52:54 2008''
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Current revision

Sterile alpha motif (SAM) domain of ephrin type-A receptor 8

PDB ID 1ucv

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OCA

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