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2zau

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{{Seed}}
 
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[[Image:2zau.png|left|200px]]
 
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==Crystal structure of an N-terminally truncated selenophosphate synthetase from Aquifex aeolicus==
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The line below this paragraph, containing "STRUCTURE_2zau", creates the "Structure Box" on the page.
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<StructureSection load='2zau' size='340' side='right'caption='[[2zau]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2zau]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/"aquifex_aeolicus"_huber_and_stetter_2001 "aquifex aeolicus" huber and stetter 2001]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZAU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZAU FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2zod|2zod]], [[2yye|2yye]]</div></td></tr>
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{{STRUCTURE_2zau| PDB=2zau | SCENE= }}
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">selD ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=63363 "Aquifex aeolicus" Huber and Stetter 2001])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Selenide,_water_dikinase Selenide, water dikinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.9.3 2.7.9.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zau OCA], [https://pdbe.org/2zau PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zau RCSB], [https://www.ebi.ac.uk/pdbsum/2zau PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zau ProSAT], [https://www.topsan.org/Proteins/RSGI/2zau TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/SELD_AQUAE SELD_AQUAE]] Synthesizes selenophosphate from selenide and ATP (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/za/2zau_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zau ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Selenophosphate synthetase (SPS) catalyzes the activation of selenide with ATP to synthesize selenophosphate, the reactive selenium donor for biosyntheses of both the 21st amino acid selenocysteine and 2-selenouridine nucleotides in tRNA anticodons. The crystal structure of an N-terminally (25 residues) truncated fragment of SPS (SPS-DeltaN) from Aquifex aeolicus has been determined at 2.0 A resolution. The structure revealed SPS to be a two-domain alpha/beta protein, with domain folds that are homologous to those of PurM-superfamily proteins. In the crystal, six monomers of SPS-DeltaN form a hexamer of 204 kDa, whereas the molecular weight estimated by ultracentrifugation was approximately 63 kDa, which is comparable to the calculated weight of the dimer (68 kDa).
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===Crystal structure of an N-terminally truncated selenophosphate synthetase from Aquifex aeolicus===
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Structure of an N-terminally truncated selenophosphate synthetase from Aquifex aeolicus.,Matsumoto E, Sekine SI, Akasaka R, Otta Y, Katsura K, Inoue M, Kaminishi T, Terada T, Shirouzu M, Yokoyama S Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jun 1;64(Pt, 6):453-8. Epub 2008 May 16. PMID:18540050<ref>PMID:18540050</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_18540050}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2zau" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 18540050 is the PubMed ID number.
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== References ==
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-->
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<references/>
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{{ABSTRACT_PUBMED_18540050}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Aquifex aeolicus huber and stetter 2001]]
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2ZAU is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZAU OCA].
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[[Category: Large Structures]]
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==Reference==
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Structure of an N-terminally truncated selenophosphate synthetase from Aquifex aeolicus., Matsumoto E, Sekine SI, Akasaka R, Otta Y, Katsura K, Inoue M, Kaminishi T, Terada T, Shirouzu M, Yokoyama S, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jun 1;64(Pt, 6):453-8. Epub 2008 May 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18540050 18540050]
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[[Category: Aquifex aeolicus]]
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[[Category: Selenide, water dikinase]]
[[Category: Selenide, water dikinase]]
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[[Category: Matsumoto, E.]]
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[[Category: Matsumoto, E]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Structural genomic]]
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[[Category: Sekine, S.]]
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[[Category: Sekine, S]]
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[[Category: Yokoyama, S.]]
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[[Category: Yokoyama, S]]
[[Category: Atp-binding]]
[[Category: Atp-binding]]
[[Category: Intramolecular s-s bond]]
[[Category: Intramolecular s-s bond]]
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[[Category: Nppsfa]]
[[Category: Nppsfa]]
[[Category: Nucleotide-binding]]
[[Category: Nucleotide-binding]]
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[[Category: Riken structural genomics/proteomics initiative]]
 
[[Category: Rsgi]]
[[Category: Rsgi]]
[[Category: Selenium]]
[[Category: Selenium]]
[[Category: Selenocysteine]]
[[Category: Selenocysteine]]
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[[Category: Structural genomic]]
 
[[Category: Transferase]]
[[Category: Transferase]]
[[Category: Trimer of dimer]]
[[Category: Trimer of dimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 16:04:38 2008''
 

Current revision

Crystal structure of an N-terminally truncated selenophosphate synthetase from Aquifex aeolicus

PDB ID 2zau

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