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2ecr

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{{Seed}}
 
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[[Image:2ecr.png|left|200px]]
 
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==Crystal structure of the ligand-free form of the flavin reductase component (HpaC) of 4-hydroxyphenylacetate 3-monooxygenase==
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The line below this paragraph, containing "STRUCTURE_2ecr", creates the "Structure Box" on the page.
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<StructureSection load='2ecr' size='340' side='right'caption='[[2ecr]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2ecr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ECR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ECR FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ecr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ecr OCA], [https://pdbe.org/2ecr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ecr RCSB], [https://www.ebi.ac.uk/pdbsum/2ecr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ecr ProSAT], [https://www.topsan.org/Proteins/RSGI/2ecr TOPSAN]</span></td></tr>
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{{STRUCTURE_2ecr| PDB=2ecr | SCENE= }}
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</table>
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== Function ==
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===Crystal structure of the ligand-free form of the flavin reductase component (HpaC) of 4-hydroxyphenylacetate 3-monooxygenase===
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[https://www.uniprot.org/uniprot/HPAC_THET8 HPAC_THET8] Catalyzes the reduction of free flavins (FMN, FAD and riboflavin) by NADH. Subsequently, the reduced flavins diffuse to the large HpaB component.<ref>PMID:17729270</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 17729270 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ec/2ecr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_17729270}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ecr ConSurf].
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2ECR is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ECR OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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Crystal structure of the flavin reductase component (HpaC) of 4-hydroxyphenylacetate 3-monooxygenase from Thermus thermophilus HB8: Structural basis for the flavin affinity., Kim SH, Hisano T, Iwasaki W, Ebihara A, Miki K, Proteins. 2008 Feb 15;70(3):718-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17729270 17729270]
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__TOC__
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</StructureSection>
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Crystallization and preliminary X-ray analysis of the small component of 4-hydroxyphenylacetate 3-monooxygenase (HpaC) and its cofactor complex from Thermus thermophilus HB8., Kim SH, Miyatake H, Hisano T, Ohtani N, Miki K, Acta Crystallogr D Biol Crystallogr. 2003 Dec;59(Pt 12):2275-8. Epub 2003, Nov 27. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14646093 14646093]
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[[Category: Large Structures]]
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[[Category: Thermus thermophilus]]
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[[Category: Thermus thermophilus HB8]]
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[[Category: Ebihara, A.]]
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[[Category: Ebihara A]]
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[[Category: Hisano, T.]]
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[[Category: Hisano T]]
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[[Category: Iwasaki, W.]]
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[[Category: Iwasaki W]]
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[[Category: Kim, S H.]]
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[[Category: Kim SH]]
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[[Category: Miki, K.]]
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[[Category: Miki K]]
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[[Category: Flavin diffusible]]
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[[Category: Flavin reductase]]
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[[Category: Oxidoreductase]]
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[[Category: Two-component monooxygenase]]
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[[Category: X-ray diffraction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 16:43:44 2008''
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Current revision

Crystal structure of the ligand-free form of the flavin reductase component (HpaC) of 4-hydroxyphenylacetate 3-monooxygenase

PDB ID 2ecr

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