1u0t

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{{Seed}}
 
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[[Image:1u0t.png|left|200px]]
 
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==Crystal structure of Mycobacterium tuberculosis NAD kinase==
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The line below this paragraph, containing "STRUCTURE_1u0t", creates the "Structure Box" on the page.
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<StructureSection load='1u0t' size='340' side='right'caption='[[1u0t]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1u0t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U0T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U0T FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u0t OCA], [https://pdbe.org/1u0t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u0t RCSB], [https://www.ebi.ac.uk/pdbsum/1u0t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u0t ProSAT]</span></td></tr>
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{{STRUCTURE_1u0t| PDB=1u0t | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NADK_MYCTU NADK_MYCTU] Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. It can use ATP and other nucleoside triphosphates as well as inorganic polyphosphate (poly(P)) as a source of phosphorus.[HAMAP-Rule:MF_00361]<ref>PMID:11006082</ref> <ref>PMID:15182203</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u0/1u0t_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u0t ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of Mycobacterium tuberculosis NAD kinase===
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==See Also==
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*[[NAD kinase|NAD kinase]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_15269221}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 15269221 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_15269221}}
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==About this Structure==
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1U0T is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U0T OCA].
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==Reference==
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A novel fold revealed by Mycobacterium tuberculosis NAD kinase, a key allosteric enzyme in NADP biosynthesis., Garavaglia S, Raffaelli N, Finaurini L, Magni G, Rizzi M, J Biol Chem. 2004 Sep 24;279(39):40980-6. Epub 2004 Jul 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15269221 15269221]
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[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: Finaurini, L.]]
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[[Category: Finaurini L]]
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[[Category: Garavaglia, S.]]
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[[Category: Garavaglia S]]
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[[Category: Magni, G.]]
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[[Category: Magni G]]
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[[Category: Raffaelli, N.]]
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[[Category: Raffaelli N]]
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[[Category: Rizzi, M.]]
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[[Category: Rizzi M]]
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[[Category: TBSGC, TB Structural Genomics Consortium.]]
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[[Category: Alpha-beta]]
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[[Category: Beta sandwich]]
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[[Category: Protein structure initiative]]
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[[Category: Psi]]
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[[Category: Structural genomic]]
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[[Category: Tb structural genomics consortium]]
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[[Category: Tbsgc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 17:08:07 2008''
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Current revision

Crystal structure of Mycobacterium tuberculosis NAD kinase

PDB ID 1u0t

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