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1wy5

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{{Seed}}
 
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[[Image:1wy5.png|left|200px]]
 
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==Crystal structure of isoluecyl-tRNA lysidine synthetase==
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The line below this paragraph, containing "STRUCTURE_1wy5", creates the "Structure Box" on the page.
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<StructureSection load='1wy5' size='340' side='right'caption='[[1wy5]], [[Resolution|resolution]] 2.42&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1wy5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WY5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WY5 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.42&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wy5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wy5 OCA], [https://pdbe.org/1wy5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wy5 RCSB], [https://www.ebi.ac.uk/pdbsum/1wy5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wy5 ProSAT], [https://www.topsan.org/Proteins/RSGI/1wy5 TOPSAN]</span></td></tr>
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{{STRUCTURE_1wy5| PDB=1wy5 | SCENE= }}
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</table>
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== Function ==
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===Crystal structure of isoluecyl-tRNA lysidine synthetase===
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[https://www.uniprot.org/uniprot/TILS_AQUAE TILS_AQUAE] Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_15894617}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 15894617 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wy/1wy5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_15894617}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wy5 ConSurf].
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1WY5 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WY5 OCA].
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<div style="clear:both"></div>
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__TOC__
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==Reference==
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</StructureSection>
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Structural basis for lysidine formation by ATP pyrophosphatase accompanied by a lysine-specific loop and a tRNA-recognition domain., Nakanishi K, Fukai S, Ikeuchi Y, Soma A, Sekine Y, Suzuki T, Nureki O, Proc Natl Acad Sci U S A. 2005 May 24;102(21):7487-92. Epub 2005 May 13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15894617 15894617]
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[[Category: Aquifex aeolicus]]
[[Category: Aquifex aeolicus]]
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[[Category: Fukai, S.]]
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[[Category: Large Structures]]
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[[Category: Ikeuchi, Y.]]
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[[Category: Fukai S]]
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[[Category: Nakanishi, K.]]
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[[Category: Ikeuchi Y]]
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[[Category: Nureki, O.]]
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[[Category: Nakanishi K]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Nureki O]]
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[[Category: Sekine, Y.]]
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[[Category: Sekine Y]]
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[[Category: Soma, A.]]
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[[Category: Soma A]]
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[[Category: Suzuki, T.]]
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[[Category: Suzuki T]]
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[[Category: N-type atp-ppase]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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[[Category: Translation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 17:40:22 2008''
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Current revision

Crystal structure of isoluecyl-tRNA lysidine synthetase

PDB ID 1wy5

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