2ayj

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{{Seed}}
 
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[[Image:2ayj.png|left|200px]]
 
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==Solution structure of 50S ribosomal protein L40e from Sulfolobus solfataricus==
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The line below this paragraph, containing "STRUCTURE_2ayj", creates the "Structure Box" on the page.
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<StructureSection load='2ayj' size='340' side='right'caption='[[2ayj]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2ayj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AYJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AYJ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_2ayj| PDB=2ayj | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ayj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ayj OCA], [https://pdbe.org/2ayj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ayj RCSB], [https://www.ebi.ac.uk/pdbsum/2ayj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ayj ProSAT], [https://www.topsan.org/Proteins/NESGC/2ayj TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RL40_SACS2 RL40_SACS2]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ay/2ayj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ayj ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The ribosomal protein L40E from archaeon Sulfolobus solfataricus is a component of the 50S ribosomal subunit. L40E is a 56-residue, highly basic protein that contains a C4 zinc finger motif, CRKC_X(10)_CRRC. Homologs are found in both archaea and eukaryotes but are not present in bacteria. Eukaryotic genomes encode L40E as a ubiquitin-fusion protein. L40E was absent from the crystal structure of euryarchaeota 50S ribosomal subunit. Here we report the three-dimensional solution structure of L40E by NMR spectroscopy. The structure of L40E is a three-stranded beta-sheet with a simple beta2beta1beta3 topology. There are two unique characteristics revealed by the structure. First, a large and ordered beta2-beta3 loop twists to pack across the one side of the protein. L40E contains a buried polar cluster comprising Lys19, Lys20, Cys22, Asn29, and Cys36. Second, the surface of L40E is almost entirely positively charged. Ten conserved basic residues are positioned on the two sides of the surface. It is likely that binding of zinc is essential in stabilizing the tertiary structure of L40E to act as a scaffold to create a broad positively charged surface for RNA and/or protein recognition.
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===Solution structure of 50S ribosomal protein L40e from Sulfolobus solfataricus===
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Solution structure of ribosomal protein L40E, a unique C4 zinc finger protein encoded by archaeon Sulfolobus solfataricus.,Wu B, Lukin J, Yee A, Lemak A, Semesi A, Ramelot TA, Kennedy MA, Arrowsmith CH Protein Sci. 2008 Mar;17(3):589-96. Epub 2008 Jan 24. PMID:18218710<ref>PMID:18218710</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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2AYJ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AYJ OCA].
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<div class="pdbe-citations 2ayj" style="background-color:#fffaf0;"></div>
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[[Category: Sulfolobus solfataricus]]
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== References ==
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[[Category: Arrowsmith, C H.]]
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<references/>
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[[Category: Edward, A.]]
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__TOC__
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[[Category: Kennedy, M.]]
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</StructureSection>
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[[Category: Lemak, A.]]
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[[Category: Large Structures]]
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[[Category: Lukin, J.]]
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[[Category: Saccharolobus solfataricus]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Arrowsmith CH]]
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[[Category: Ramelot, T.]]
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[[Category: Edward A]]
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[[Category: Semesi, A.]]
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[[Category: Kennedy M]]
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[[Category: Wu, B.]]
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[[Category: Lemak A]]
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[[Category: Yee, A.]]
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[[Category: Lukin J]]
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[[Category: Beta-strand protein]]
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[[Category: Ramelot T]]
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[[Category: Nesg]]
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[[Category: Semesi A]]
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[[Category: Northeast structural genomics consortium]]
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[[Category: Wu B]]
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[[Category: Protein structure initiative]]
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[[Category: Yee A]]
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[[Category: Psi]]
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[[Category: Structural genomic]]
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[[Category: Zn-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 17:43:31 2008''
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Current revision

Solution structure of 50S ribosomal protein L40e from Sulfolobus solfataricus

PDB ID 2ayj

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