2oar

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(→Reference - polishing)
Current revision (00:16, 28 December 2023) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2oar.png|left|200px]]
 
-
<!--
+
==Mechanosensitive Channel of Large Conductance (MscL)==
-
The line below this paragraph, containing "STRUCTURE_2oar", creates the "Structure Box" on the page.
+
<StructureSection load='2oar' size='340' side='right'caption='[[2oar]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2oar]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Ra Mycobacterium tuberculosis H37Ra]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1msl 1msl]. The November 2008 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Mechanosensitive Channels'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2008_11 10.2210/rcsb_pdb/mom_2008_11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OAR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OAR FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AU:GOLD+ION'>AU</scene></td></tr>
-
{{STRUCTURE_2oar| PDB=2oar | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oar FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oar OCA], [https://pdbe.org/2oar PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oar RCSB], [https://www.ebi.ac.uk/pdbsum/2oar PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oar ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/MSCL_MYCTA MSCL_MYCTA] Channel that opens in response to stretch forces in the membrane lipid bilayer. The force required to trigger channel opening depends on the nature of the membrane lipids; the presence of phosphatidylinositol enhances mechanosensitivity of the channel. May participate in the regulation of osmotic pressure changes within the cell.[UniProtKB:P9WJN5]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oa/2oar_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2oar ConSurf].
 +
<div style="clear:both"></div>
-
===Mechanosensitive Channel of Large Conductance (MscL)===
+
==See Also==
-
 
+
*[[Ion channels 3D structures|Ion channels 3D structures]]
-
==Model of Channel Opening==
+
__TOC__
-
Theoretical models<ref>The theoretical models were deposited in the [[PDB]] (before it stopped accepting theoretical models) as [[1kyk]], [[1kyl]], and [[1kym]].</ref> the <scene name='Goodsell_Sandbox/1kyk/1'>closed, </scene><scene name='Goodsell_Sandbox/1kyl/1'>intermediate,</scene> and <scene name='Goodsell_Sandbox/1kym/1'>open</scene> forms of the channel have been generated based on data from electron paramagnetic resonance spectroscopy, using mutant forms of the protein with spin labels attached to engineered cysteine amino acids in the transmembrane segments<ref>Open channel structure of MscL and the gating mechanism of mechanosensitive channels. Perozo, E, Cortes DM, Sompornpisut, P, Kloda, A, Martinac, B. Nature 2002, 418, 942-948. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12198539 12198539]</ref>.
+
</StructureSection>
-
 
+
[[Category: Large Structures]]
-
<!--
+
[[Category: Mechanosensitive Channels]]
-
The line below this paragraph, {{ABSTRACT_PUBMED_9856938}}, adds the Publication Abstract to the page
+
[[Category: Mycobacterium tuberculosis H37Ra]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 9856938 is the PubMed ID number.
+
[[Category: RCSB PDB Molecule of the Month]]
-
-->
+
[[Category: Chang G]]
-
{{ABSTRACT_PUBMED_9856938}}
+
[[Category: Lee AT]]
-
 
+
[[Category: Rees DC]]
-
==About this Structure==
+
[[Category: Spencer RH]]
-
2OAR <ref>Structure of the MscL homolog from Mycobacterium tuberculosis: a gated mechanosensitive ion channel., Chang G, Spencer RH, Lee AT, Barclay MT, Rees DC, Science. 1998 Dec 18;282(5397):2220-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9856938 9856938]</ref> is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1msl 1msl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OAR OCA].
+
[[Category: Steinbacher S]]
-
 
+
[[Category: Strop P]]
-
 
+
-
==References and Notes==
+
-
<references/>
+
-
[[Category: Mycobacterium tuberculosis]]
+
-
[[Category: Single protein]]
+
-
[[Category: Chang, G.]]
+
-
[[Category: Lee, A T.]]
+
-
[[Category: Rees, D C.]]
+
-
[[Category: Spencer, R H.]]
+
-
[[Category: Steinbacher, S.]]
+
-
[[Category: Strop, P.]]
+
-
[[Category: Stretch activated ion channel mechanosensitive]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 20 12:12:19 2008''
+

Current revision

Mechanosensitive Channel of Large Conductance (MscL)

PDB ID 2oar

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA, Eric Martz, David S. Goodsell, Eran Hodis

Retrieved from "http://52.214.119.220/wiki/index.php/2oar"
Personal tools