This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.




2ae4

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:40, 13 March 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2ae4.png|left|200px]]
 
-
<!--
+
==Glutaryl 7-Aminocephalosporanic Acid Acylase: mutational study of activation mechanism==
-
The line below this paragraph, containing "STRUCTURE_2ae4", creates the "Structure Box" on the page.
+
<StructureSection load='2ae4' size='340' side='right'caption='[[2ae4]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2ae4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_sp._GK16 Pseudomonas sp. GK16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AE4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AE4 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
{{STRUCTURE_2ae4| PDB=2ae4 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ae4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ae4 OCA], [https://pdbe.org/2ae4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ae4 RCSB], [https://www.ebi.ac.uk/pdbsum/2ae4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ae4 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/G7AC_PSEU7 G7AC_PSEU7] Catalyzes the deacylation of 7 beta-(4-carboxybutanamido)cephalosporanic acid (glutaryl-7-aminocephalosporanic acid or GL-7-ACA) to 7-aminocephalosporanic acid (7-ACA).<ref>PMID:2993240</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ae/2ae4_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ae4 ConSurf].
 +
<div style="clear:both"></div>
-
===Glutaryl 7-Aminocephalosporanic Acid Acylase: mutational study of activation mechanism===
+
==See Also==
-
 
+
*[[Cephalosporin acylase 3D structures|Cephalosporin acylase 3D structures]]
-
 
+
== References ==
-
<!--
+
<references/>
-
The line below this paragraph, {{ABSTRACT_PUBMED_16446446}}, adds the Publication Abstract to the page
+
__TOC__
-
(as it appears on PubMed at http://www.pubmed.gov), where 16446446 is the PubMed ID number.
+
</StructureSection>
-
-->
+
[[Category: Large Structures]]
-
{{ABSTRACT_PUBMED_16446446}}
+
[[Category: Pseudomonas sp. GK16]]
-
 
+
[[Category: Cho KJ]]
-
==About this Structure==
+
[[Category: Kim JK]]
-
2AE4 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Pseudomonas_sp._gk16 Pseudomonas sp. gk16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AE4 OCA].
+
[[Category: Kim KH]]
-
 
+
[[Category: Kim SH]]
-
==Reference==
+
[[Category: Park SS]]
-
Insight into autoproteolytic activation from the structure of cephalosporin acylase: a protein with two proteolytic chemistries., Kim JK, Yang IS, Shin HJ, Cho KJ, Ryu EK, Kim SH, Park SS, Kim KH, Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1732-7. Epub 2006 Jan 30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16446446 16446446]
+
[[Category: Ryu EK]]
-
[[Category: Penicillin amidase]]
+
[[Category: Shin HJ]]
-
[[Category: Protein complex]]
+
[[Category: Yang IS]]
-
[[Category: Pseudomonas sp. gk16]]
+
-
[[Category: Cho, K J.]]
+
-
[[Category: Kim, J K.]]
+
-
[[Category: Kim, K H.]]
+
-
[[Category: Kim, S H.]]
+
-
[[Category: Park, S S.]]
+
-
[[Category: Ryu, E K.]]
+
-
[[Category: Shin, H J.]]
+
-
[[Category: Yang, I S.]]
+
-
[[Category: Autoproteolysis]]
+
-
[[Category: Cephalosporin acylase]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Intermediate structure]]
+
-
[[Category: Precursor activation]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 26 20:28:13 2008''
+

Current revision

Glutaryl 7-Aminocephalosporanic Acid Acylase: mutational study of activation mechanism

PDB ID 2ae4

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ae4"
Personal tools