2jkf

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{{Seed}}
 
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[[Image:2jkf.png|left|200px]]
 
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==Plasmodium falciparum profilin==
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The line below this paragraph, containing "STRUCTURE_2jkf", creates the "Structure Box" on the page.
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<StructureSection load='2jkf' size='340' side='right'caption='[[2jkf]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2jkf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JKF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JKF FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.31&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jkf OCA], [https://pdbe.org/2jkf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jkf RCSB], [https://www.ebi.ac.uk/pdbsum/2jkf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jkf ProSAT]</span></td></tr>
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{{STRUCTURE_2jkf| PDB=2jkf | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PROF_PLAFX PROF_PLAFX] Essential for the invasive blood stages of the parasite. Binds to proline rich sequences in various regulatory formin-like proteins and also to membrane phospholipids. Binds to actin and affects the structure of the cytoskeleton. Weakly sequesters actin monomers.<ref>PMID:19000816</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jk/2jkf_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jkf ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Profilins are key regulators of actin dynamics. They sequester actin monomers, forming a pool for rapid polymer formation stimulated by proteins such as formins. Apicomplexan parasites utilize a highly specialized microfilament system for motility and host cell invasion. Their genomes encode only a small number of divergent actin regulators. We present the first crystal structure of an apicomplexan profilin, that of the malaria parasite Plasmodium falciparum, alone and in complex with a polyproline ligand peptide. The most striking feature of Plasmodium profilin is a unique minidomain consisting of a large beta-hairpin extension common to all apicomplexan parasites, and an acidic loop specific for Plasmodium species. Reverse genetics in the rodent malaria model, Plasmodium berghei, suggests that profilin is essential for the invasive blood stages of the parasite. Together, our data establish the structural basis for understanding the functions of profilin in the malaria parasite.
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===PLASMODIUM FALCIPARUM PROFILIN===
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Structural basis for parasite-specific functions of the divergent profilin of Plasmodium falciparum.,Kursula I, Kursula P, Ganter M, Panjikar S, Matuschewski K, Schuler H Structure. 2008 Nov 12;16(11):1638-48. PMID:19000816<ref>PMID:19000816</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2jkf" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_19000816}}, adds the Publication Abstract to the page
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*[[Profilin 3D Structures|Profilin 3D Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19000816 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19000816}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2JKF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JKF OCA].
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==Reference==
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Structural Basis for Parasite-Specific Functions of the Divergent Profilin of Plasmodium falciparum., Kursula I, Kursula P, Ganter M, Panjikar S, Matuschewski K, Schuler H, Structure. 2008 Nov;16(11):1638-48. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/19000816 19000816]
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[[Category: Plasmodium falciparum]]
[[Category: Plasmodium falciparum]]
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[[Category: Single protein]]
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[[Category: Ganter M]]
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[[Category: Ganter, M.]]
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[[Category: Kursula I]]
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[[Category: Kursula, I.]]
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[[Category: Kursula P]]
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[[Category: Kursula, P.]]
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[[Category: Matuschewski K]]
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[[Category: Matuschewski, K.]]
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[[Category: Panjikar S]]
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[[Category: Panjikar, S.]]
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[[Category: Schueler H]]
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[[Category: Schueler, H.]]
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[[Category: Actin filament structural protein]]
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[[Category: Cytoskeleton]]
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[[Category: Malaria]]
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[[Category: Plasmodium falciparum]]
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[[Category: Profilin]]
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[[Category: Proline-rich ligand]]
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[[Category: Protein-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 26 20:31:59 2008''
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Current revision

Plasmodium falciparum profilin

PDB ID 2jkf

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