3fbk

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(New page: '''Unreleased structure''' The entry 3fbk is ON HOLD Authors: Forouhar, F., Lew, S., Seetharaman, J., Mao, L., Xiao, R., Ciccosanti, C., Foote, E.L., Shastry, R., Everett, J.K., Nair, R...)
Current revision (09:33, 6 December 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 3fbk is ON HOLD
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==Crystal structure of the C2 domain of the human regulator of G-protein signaling 3 isoform 6 (RGP3), Northeast Structural Genomics Consortium Target HR5550A==
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<StructureSection load='3fbk' size='340' side='right'caption='[[3fbk]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3fbk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FBK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FBK FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fbk OCA], [https://pdbe.org/3fbk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fbk RCSB], [https://www.ebi.ac.uk/pdbsum/3fbk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fbk ProSAT], [https://www.topsan.org/Proteins/NESGC/3fbk TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RGS3_HUMAN RGS3_HUMAN] Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases.<ref>PMID:8602223</ref> <ref>PMID:9858594</ref> <ref>PMID:10749886</ref> <ref>PMID:11294858</ref>
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Authors: Forouhar, F., Lew, S., Seetharaman, J., Mao, L., Xiao, R., Ciccosanti, C., Foote, E.L., Shastry, R., Everett, J.K., Nair, R., Acton, T.B., Rost, B., Montelione, G.T., Hunt, J.F., Tong, L., Northeast Structural Genomics Consortium (NESG)
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==See Also==
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*[[Regulator of G-protein signaling 3D structures|Regulator of G-protein signaling 3D structures]]
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Description: Crystal structure of the C2 domain of the human regulator of G-protein signaling 3 isoform 6 (RGP3), Northeast Structural Genomics Consortium Target HR5550A
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== References ==
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<references/>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 3 23:23:45 2008''
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Acton TB]]
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[[Category: Ciccosanti C]]
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[[Category: Everett JK]]
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[[Category: Foote EL]]
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[[Category: Forouhar F]]
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[[Category: Hunt JF]]
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[[Category: Lew S]]
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[[Category: Mao L]]
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[[Category: Montelione GT]]
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[[Category: Nair R]]
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[[Category: Rost B]]
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[[Category: Seetharaman J]]
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[[Category: Shastry R]]
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[[Category: Tong L]]
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[[Category: Xiao R]]

Current revision

Crystal structure of the C2 domain of the human regulator of G-protein signaling 3 isoform 6 (RGP3), Northeast Structural Genomics Consortium Target HR5550A

PDB ID 3fbk

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