2esg

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{{Seed}}
 
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[[Image:2esg.png|left|200px]]
 
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==Solution structure of the complex between immunoglobulin IgA1 and human serum albumin==
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The line below this paragraph, containing "STRUCTURE_2esg", creates the "Structure Box" on the page.
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<StructureSection load='2esg' size='340' side='right'caption='[[2esg]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2esg]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ESG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ESG FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray solution scattering</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2esg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2esg OCA], [https://pdbe.org/2esg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2esg RCSB], [https://www.ebi.ac.uk/pdbsum/2esg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2esg ProSAT]</span></td></tr>
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{{STRUCTURE_2esg| PDB=2esg | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/IGHA1_HUMAN IGHA1_HUMAN] Note=A chromosomal aberration involving IGHA1 is found in multiple myeloma (MM) cell lines. Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein.
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== Function ==
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[https://www.uniprot.org/uniprot/IGHA1_HUMAN IGHA1_HUMAN] Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/es/2esg_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2esg ConSurf].
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<div style="clear:both"></div>
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===Solution structure of the complex between immunoglobulin IgA1 and human serum albumin===
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==See Also==
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*[[Albumin 3D structures|Albumin 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_16376934}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16376934 is the PubMed ID number.
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-->
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{{ABSTRACT_PUBMED_16376934}}
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==Disease==
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Known disease associated with this structure: Analbuminemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=103600 103600]], Dysalbuminemic hyperthyroxinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=103600 103600]], Dysalbuminemic hyperzincemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=103600 103600]]
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==About this Structure==
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2ESG is a 5 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ESG OCA].
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==Reference==
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Purification, properties and extended solution structure of the complex formed between human immunoglobulin A1 and human serum albumin by scattering and ultracentrifugation., Almogren A, Furtado PB, Sun Z, Perkins SJ, Kerr MA, J Mol Biol. 2006 Feb 17;356(2):413-31. Epub 2005 Dec 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16376934 16376934]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
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[[Category: Large Structures]]
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[[Category: Antibody]]
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[[Category: Almogren A]]
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[[Category: Human serum albumin]]
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[[Category: Furtado PB]]
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[[Category: Immune system/transport protein complex]]
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[[Category: Kerr MA]]
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[[Category: Immunoglobulin]]
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[[Category: Perkins SJ]]
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[[Category: Sun Z]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 10 09:12:55 2008''
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Current revision

Solution structure of the complex between immunoglobulin IgA1 and human serum albumin

PDB ID 2esg

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OCA

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