2k5s

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{{Seed}}
 
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[[Image:2k5s.jpg|left|200px]]
 
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==YmoA==
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The line below this paragraph, containing "STRUCTURE_2k5s", creates the "Structure Box" on the page.
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<StructureSection load='2k5s' size='340' side='right'caption='[[2k5s]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2k5s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2jvp 2jvp]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K5S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K5S FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k5s OCA], [https://pdbe.org/2k5s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k5s RCSB], [https://www.ebi.ac.uk/pdbsum/2k5s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k5s ProSAT]</span></td></tr>
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{{STRUCTURE_2k5s| PDB=2k5s | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/YMOA_YERPE YMOA_YERPE] Modulates the thermoregulation of VirF, and hence the yop regulon, as well as the expression of the enterotoxin gene yst. It is supposed to be involved in chromosome structure and DNA topology; probably by means of compaction of DNA (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k5/2k5s_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k5s ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The high-resolution solution structure of Yersinia modulating protein YmoA is presented. The protein is all helical with the first three of four helices forming the central core. Structures calculated with only NOE and dihedral restraints exhibit a backbone root-mean-square deviation (rmsd) of 0.77 A. Upon refinement against Halpha-Calpha, HN-N, and Calpha-C' J-modulated residual dipolar couplings, the backbone rmsd improves to 0.22 A. YmoA has a high amino acid sequence identity to and a similar overall fold to Escherichia coli hemolysin expression modulating protein Hha; however, structural differences do occur. YmoA is also found to be structurally similar to the histone-like nucleoid structuring protein H-NS, indicating that YmoA may intercalate into higher-order H-NS suprastructuring by substituting for an H-NS dimer.
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===YmoA===
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The high-precision solution structure of Yersinia modulating protein YmoA provides insight into interaction with H-NS.,McFeeters RL, Altieri AS, Cherry S, Tropea JE, Waugh DS, Byrd RA Biochemistry. 2007 Dec 11;46(49):13975-82. Epub 2007 Nov 15. PMID:18001134<ref>PMID:18001134</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_18001134}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2k5s" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 18001134 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18001134}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2K5S is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2jvp 2jvp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K5S OCA].
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==Reference==
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The high-precision solution structure of Yersinia modulating protein YmoA provides insight into interaction with H-NS., McFeeters RL, Altieri AS, Cherry S, Tropea JE, Waugh DS, Byrd RA, Biochemistry. 2007 Dec 11;46(49):13975-82. Epub 2007 Nov 15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18001134 18001134]
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[[Category: Yersinia pestis]]
[[Category: Yersinia pestis]]
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[[Category: Byrd, R.]]
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[[Category: Byrd R]]
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[[Category: McFeeters, R L.]]
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[[Category: McFeeters RL]]
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[[Category: Dna-binding]]
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[[Category: Protein]]
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[[Category: Transcription regulator]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 10 14:50:07 2008''
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Current revision

YmoA

PDB ID 2k5s

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