2k4u

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:02, 10 November 2021) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2k4u.jpg|left|200px]]
 
-
<!--
+
==Solution structure of the SCORPION TOXIN ADWX-1==
-
The line below this paragraph, containing "STRUCTURE_2k4u", creates the "Structure Box" on the page.
+
<StructureSection load='2k4u' size='340' side='right'caption='[[2k4u]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2k4u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Buthus_martensi Buthus martensi]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K4U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K4U FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k4u OCA], [https://pdbe.org/2k4u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k4u RCSB], [https://www.ebi.ac.uk/pdbsum/2k4u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k4u ProSAT]</span></td></tr>
-
-->
+
</table>
-
{{STRUCTURE_2k4u| PDB=2k4u | SCENE= }}
+
== Function ==
 +
[[https://www.uniprot.org/uniprot/KAX36_MESMA KAX36_MESMA]] Blocks voltage-gated potassium channels. At 2 uM, blocks rat Kv1.1/KCNA1 and Kv1.3/KCNA3, has a strong effect on rat Kv1.2/KCNA2 and Kv1.6/KCNA6 as well as a moderate effect on Shaker IR.<ref>PMID:9354615</ref> <ref>PMID:20713119</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k4/2k4u_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k4u ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The low selectivity of Kv1 peptide inhibitors for specific isoforms makes them poor candidates for the development of theraputics. Using combined approaches, we showed that the Kv1 turret is the critical determinant for ADWX-1 peptide inhibitor selectivity of Kv1.3 over Kv1.1. Mutation of Kv1.1 turret residues to match the sequence of Kv1.3 lead to increased inhibition of Kv1.1 activity. These studies may lead to improvements in peptide inhibitor drug development.
-
===Solution structure of the SCORPION TOXIN ADWX-1===
+
Different Residues in Channel Turret Determining the Selectivity of ADWX-1 Inhibitor Peptide between Kv1.1 and Kv1.3 Channels.,Yin SJ, Jiang L, Yi H, Han S, Yang DW, Liu ML, Liu H, Cao ZJ, Wu YL, Li WX J Proteome Res. 2008 Nov 7;7(11):4890-4897. Epub 2008 Oct 21. PMID:18937510<ref>PMID:18937510</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 2k4u" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_18937510}}, adds the Publication Abstract to the page
+
*[[Potassium channel toxin 3D structures|Potassium channel toxin 3D structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 18937510 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_18937510}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Buthus martensi]]
-
2K4U is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mesobuthus_martensii Mesobuthus martensii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K4U OCA].
+
[[Category: Large Structures]]
-
 
+
[[Category: Cao, Z J]]
-
==Reference==
+
[[Category: Han, S]]
-
Different Residues in Channel Turret Determining the Selectivity of ADWX-1 Inhibitor Peptide between Kv1.1 and Kv1.3 Channels., Yin SJ, Jiang L, Yi H, Han S, Yang DW, Liu ML, Liu H, Cao ZJ, Wu YL, Li WX, J Proteome Res. 2008 Nov 7;7(11):4890-4897. Epub 2008 Oct 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18937510 18937510]
+
[[Category: Jiang, L]]
-
[[Category: Mesobuthus martensii]]
+
[[Category: Li, W X]]
-
[[Category: Cao, Z J.]]
+
[[Category: Liu, H]]
-
[[Category: Han, S.]]
+
[[Category: Liu, M L]]
-
[[Category: Jiang, L.]]
+
[[Category: Wu, Y L]]
-
[[Category: Li, W X.]]
+
[[Category: Yang, D W]]
-
[[Category: Liu, H.]]
+
[[Category: Yi, H]]
-
[[Category: Liu, M L.]]
+
[[Category: Yin, S J]]
-
[[Category: Wu, Y L.]]
+
-
[[Category: Yang, D W.]]
+
-
[[Category: Yi, H.]]
+
-
[[Category: Yin, S J.]]
+
[[Category: Adwx-1 peptide selectivity]]
[[Category: Adwx-1 peptide selectivity]]
[[Category: Amidation]]
[[Category: Amidation]]
Line 46: Line 57:
[[Category: Structural basis]]
[[Category: Structural basis]]
[[Category: Toxin]]
[[Category: Toxin]]
- 
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 10 14:52:02 2008''
 

Current revision

Solution structure of the SCORPION TOXIN ADWX-1

PDB ID 2k4u

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2k4u"
Personal tools