3cf8

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{{Seed}}
 
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[[Image:3cf8.jpg|left|200px]]
 
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==Crystal structure of (3R)-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ) from Helicobacter pylori in complex with quercetin==
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The line below this paragraph, containing "STRUCTURE_3cf8", creates the "Structure Box" on the page.
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<StructureSection load='3cf8' size='340' side='right'caption='[[3cf8]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3cf8]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CF8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CF8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=QUE:3,5,7,3,4-PENTAHYDROXYFLAVONE'>QUE</scene></td></tr>
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{{STRUCTURE_3cf8| PDB=3cf8 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cf8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cf8 OCA], [https://pdbe.org/3cf8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cf8 RCSB], [https://www.ebi.ac.uk/pdbsum/3cf8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cf8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q5G940_HELPX Q5G940_HELPX] Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.[HAMAP-Rule:MF_00406] Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity).[SAAS:SAAS00205551]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cf/3cf8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cf8 ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of (3R)-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ) from Helicobacter pylori in complex with quercetin===
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==See Also==
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*[[Beta-hydroxyacyl-acyl carrier protein dehydratase 3D structures|Beta-hydroxyacyl-acyl carrier protein dehydratase 3D structures]]
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__TOC__
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 18780820 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18780820}}
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==About this Structure==
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3CF8 is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CF8 OCA].
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==Reference==
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Three flavonoids targeting the beta-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: crystal structure characterization with enzymatic inhibition assay., Zhang L, Kong Y, Wu D, Zhang H, Wu J, Chen J, Ding J, Hu L, Jiang H, Shen X, Protein Sci. 2008 Nov;17(11):1971-8. Epub 2008 Sep 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18780820 18780820]
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[[Category: Helicobacter pylori]]
[[Category: Helicobacter pylori]]
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[[Category: Jiang, H.]]
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[[Category: Large Structures]]
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[[Category: Liu, W.]]
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[[Category: Jiang H]]
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[[Category: Shen, X.]]
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[[Category: Liu W]]
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[[Category: Wu, D.]]
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[[Category: Shen X]]
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[[Category: Zhang, L.]]
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[[Category: Wu D]]
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[[Category: Cytoplasm]]
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[[Category: Zhang L]]
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[[Category: Fabz complex]]
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[[Category: Lipid a biosynthesis]]
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[[Category: Lipid synthesis]]
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[[Category: Lyase]]
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[[Category: Quercetin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 10 15:03:34 2008''
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Current revision

Crystal structure of (3R)-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ) from Helicobacter pylori in complex with quercetin

PDB ID 3cf8

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