3f6q

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{{Seed}}
 
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[[Image:3f6q.png|left|200px]]
 
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==Crystal structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain==
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The line below this paragraph, containing "STRUCTURE_3f6q", creates the "Structure Box" on the page.
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<StructureSection load='3f6q' size='340' side='right'caption='[[3f6q]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3f6q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F6Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F6Q FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3f6q| PDB=3f6q | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f6q OCA], [https://pdbe.org/3f6q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f6q RCSB], [https://www.ebi.ac.uk/pdbsum/3f6q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f6q ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ILK_HUMAN ILK_HUMAN] Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f6/3f6q_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3f6q ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The heterotrimeric complex between integrin-linked kinase (ILK), PINCH, and parvin is an essential signaling platform, serving as a convergence point for integrin and growth-factor signaling and regulating cell adhesion, spreading, and migration. We report a 1.6-A crystal structure of the ILK ankyrin repeat domain bound to the PINCH1 LIM1 domain, revealing the molecular basis of ILK-PINCH interactions and providing a structural description of this region of ILK. This structure identifies 5 ankyrin repeats in ILK, explains previous deletion mutagenesis data, permits identification of ILK and PINCH1 point mutations that disrupt the interaction, shows how zincs are coordinated by PINCH1 LIM1, and suggests that conformational flexibility and twisting between the 2 zinc fingers within the LIM1 domain may be important for ILK binding. These data provide an atomic-resolution description of a key interaction in the ILK-PINCH-parvin scaffolding complex.
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===Crystal structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain===
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The structural basis of integrin-linked kinase-PINCH interactions.,Chiswell BP, Zhang R, Murphy JW, Boggon TJ, Calderwood DA Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20677-82. Epub 2008 Dec 12. PMID:19074270<ref>PMID:19074270</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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3F6Q is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F6Q OCA].
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<div class="pdbe-citations 3f6q" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Large Structures]]
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[[Category: Boggon, T J.]]
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[[Category: Boggon TJ]]
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[[Category: Calderwood, D A.]]
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[[Category: Calderwood DA]]
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[[Category: Chiswell, B P.]]
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[[Category: Chiswell BP]]
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[[Category: Acetylation]]
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[[Category: Ank]]
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[[Category: Ank repeat]]
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[[Category: Ankyrin repeat]]
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[[Category: Atp-binding]]
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[[Category: Cell junction]]
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[[Category: Cell membrane]]
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[[Category: Ilk]]
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[[Category: Integrin-linked kinase]]
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[[Category: Integrin-mediated signaling]]
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[[Category: Ipp]]
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[[Category: Kinase]]
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[[Category: Lim]]
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[[Category: Lim domain]]
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[[Category: Membrane]]
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[[Category: Metal-binding]]
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[[Category: Nucleotide-binding]]
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[[Category: Phosphoprotein]]
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[[Category: Pinch]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: Signaling protein/signaling protein complex]]
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[[Category: Transferase]]
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[[Category: Transferase/metal binding protein complex]]
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[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 10 15:27:55 2008''
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Current revision

Crystal structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain

PDB ID 3f6q

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