3d0n

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{{Seed}}
 
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[[Image:3d0n.png|left|200px]]
 
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==Crystal structure of human carbonic anhydrase XIII==
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The line below this paragraph, containing "STRUCTURE_3d0n", creates the "Structure Box" on the page.
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<StructureSection load='3d0n' size='340' side='right'caption='[[3d0n]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3d0n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D0N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D0N FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3d0n| PDB=3d0n | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d0n OCA], [https://pdbe.org/3d0n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d0n RCSB], [https://www.ebi.ac.uk/pdbsum/3d0n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d0n ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CAH13_HUMAN CAH13_HUMAN] Reversible hydration of carbon dioxide.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d0/3d0n_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3d0n ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The cytosolic isoform XIII is a recently discovered member of the human carbonic anhydrase (hCA, EC 4.2.1.1) family. It is selectively expressed among other tissues in the reproductive organs, where it may control pH and ion balance regulation, ensuring thus proper fertilization conditions. The authors report here the X-ray crystallographic structure of this isozyme in the unbound state and in complex with a classical sulfonamide inhibitor, namely acetazolamide. A detailed comparison of the obtained structural data with those already reported for other CA isozymes provides novel insights into the catalytic properties of the members of this protein family. On the basis of the inhibitory properties of acetazolamide against various cytosolic/transmembrane isoforms and the structural differences detected within the active site of the various CA isoforms, further prospects for the design of isozyme-specific CA inhibitors are here proposed. Proteins 2008. (c) 2008 Wiley-Liss, Inc.
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===Crystal structure of human carbonic anhydrase XIII===
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Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide.,Di Fiore A, Monti SM, Hilvo M, Parkkila S, Romano V, Scaloni A, Pedone C, Scozzafava A, Supuran CT, De Simone G Proteins. 2008 Jul 10. PMID:18618712<ref>PMID:18618712</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3d0n" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_18618712}}, adds the Publication Abstract to the page
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*[[Carbonic anhydrase 3D structures|Carbonic anhydrase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 18618712 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18618712}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3D0N is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D0N OCA].
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==Reference==
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Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide., Di Fiore A, Monti SM, Hilvo M, Parkkila S, Romano V, Scaloni A, Pedone C, Scozzafava A, Supuran CT, De Simone G, Proteins. 2008 Jul 10;74(1):164-175. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18618712 18618712]
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[[Category: Carbonate dehydratase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Fiore, A Di.]]
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[[Category: Large Structures]]
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[[Category: Simone, G De.]]
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[[Category: De Simone G]]
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[[Category: Carbonic anhydrase]]
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[[Category: Di Fiore A]]
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[[Category: Lyase]]
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[[Category: Metal binding protein]]
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[[Category: Metal-binding]]
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[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 10 15:47:19 2008''
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Current revision

Crystal structure of human carbonic anhydrase XIII

PDB ID 3d0n

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