2k4f

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{{Seed}}
 
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[[Image:2k4f.png|left|200px]]
 
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==Mouse CD3epsilon Cytoplasmic Tail==
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The line below this paragraph, containing "STRUCTURE_2k4f", creates the "Structure Box" on the page.
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<StructureSection load='2k4f' size='340' side='right'caption='[[2k4f]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2k4f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K4F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K4F FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k4f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k4f OCA], [https://pdbe.org/2k4f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k4f RCSB], [https://www.ebi.ac.uk/pdbsum/2k4f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k4f ProSAT]</span></td></tr>
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{{STRUCTURE_2k4f| PDB=2k4f | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CD3E_MOUSE CD3E_MOUSE] The CD3 complex mediates signal transduction.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k4/2k4f_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k4f ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Many immune system receptors signal through cytoplasmic tyrosine-based motifs (ITAMs), but how receptor ligation results in ITAM phosphorylation remains unknown. Live-cell imaging studies showed a close interaction of the CD3epsilon cytoplasmic domain of the T cell receptor (TCR) with the plasma membrane through fluorescence resonance energy transfer between a C-terminal fluorescent protein and a membrane fluorophore. Electrostatic interactions between basic CD3epsilon residues and acidic phospholipids enriched in the inner leaflet of the plasma membrane were required for binding. The nuclear magnetic resonance structure of the lipid-bound state of this cytoplasmic domain revealed deep insertion of the two key tyrosines into the hydrophobic core of the lipid bilayer. Receptor ligation thus needs to result in unbinding of the CD3epsilon ITAM from the membrane to render these tyrosines accessible to Src kinases. Sequestration of key tyrosines into the lipid bilayer represents a previously unrecognized mechanism for control of receptor activation.
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===Mouse CD3epsilon Cytoplasmic Tail===
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Regulation of T cell receptor activation by dynamic membrane binding of the CD3epsilon cytoplasmic tyrosine-based motif.,Xu C, Gagnon E, Call ME, Schnell JR, Schwieters CD, Carman CV, Chou JJ, Wucherpfennig KW Cell. 2008 Nov 14;135(4):702-13. PMID:19013279<ref>PMID:19013279</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2k4f" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_19013279}}, adds the Publication Abstract to the page
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*[[CD3 3D structures|CD3 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19013279 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19013279}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2K4F is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K4F OCA].
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==Reference==
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Regulation of T cell receptor activation by dynamic membrane binding of the CD3epsilon cytoplasmic tyrosine-based motif., Xu C, Gagnon E, Call ME, Schnell JR, Schwieters CD, Carman CV, Chou JJ, Wucherpfennig KW, Cell. 2008 Nov 14;135(4):702-13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/19013279 19013279]
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Call, M E.]]
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[[Category: Call ME]]
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[[Category: Chou, J J.]]
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[[Category: Chou JJ]]
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[[Category: Gagnon, E E.]]
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[[Category: Gagnon EE]]
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[[Category: Schnell, J R.]]
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[[Category: Schnell JR]]
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[[Category: Schwieters, C D.]]
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[[Category: Schwieters CD]]
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[[Category: Wucherpfennig, K W.]]
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[[Category: Wucherpfennig KW]]
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[[Category: Xu, C.]]
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[[Category: Xu C]]
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[[Category: Bicelle]]
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[[Category: Cd3e]]
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[[Category: Immune system]]
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[[Category: Immunoglobulin domain]]
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[[Category: Itam]]
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[[Category: Membrane]]
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[[Category: Membrane bound protein]]
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[[Category: Phosphoprotein]]
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[[Category: Receptor]]
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[[Category: Signaling protein]]
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[[Category: Tcr]]
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[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 10 15:50:39 2008''
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Current revision

Mouse CD3epsilon Cytoplasmic Tail

PDB ID 2k4f

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