This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3emn

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:48, 21 February 2024) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:3emn.jpg|left|200px]]
 
-
<!--
+
==The Crystal Structure of Mouse VDAC1 at 2.3 A resolution==
-
The line below this paragraph, containing "STRUCTURE_3emn", creates the "Structure Box" on the page.
+
<StructureSection load='3emn' size='340' side='right'caption='[[3emn]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3emn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EMN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EMN FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MC3:1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE'>MC3</scene></td></tr>
-
{{STRUCTURE_3emn| PDB=3emn | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3emn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3emn OCA], [https://pdbe.org/3emn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3emn RCSB], [https://www.ebi.ac.uk/pdbsum/3emn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3emn ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/VDAC1_MOUSE VDAC1_MOUSE] Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.<ref>PMID:10716730</ref> <ref>PMID:15477379</ref> <ref>PMID:18988731</ref>
-
===The Crystal Structure of Mouse VDAC1 at 2.3 A resolution===
+
==See Also==
-
 
+
*[[Ion channels 3D structures|Ion channels 3D structures]]
-
 
+
== References ==
-
<!--
+
<references/>
-
The line below this paragraph, {{ABSTRACT_PUBMED_18988731}}, adds the Publication Abstract to the page
+
__TOC__
-
(as it appears on PubMed at http://www.pubmed.gov), where 18988731 is the PubMed ID number.
+
</StructureSection>
-
-->
+
[[Category: Large Structures]]
-
{{ABSTRACT_PUBMED_18988731}}
+
-
 
+
-
==About this Structure==
+
-
3EMN is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EMN OCA].
+
-
 
+
-
==Reference==
+
-
The crystal structure of mouse VDAC1 at 2.3 A resolution reveals mechanistic insights into metabolite gating., Ujwal R, Cascio D, Colletier JP, Faham S, Zhang J, Toro L, Ping P, Abramson J, Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17742-7. Epub 2008 Nov 6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18988731 18988731]
+
[[Category: Mus musculus]]
[[Category: Mus musculus]]
-
[[Category: Abramson, J.]]
+
[[Category: Abramson J]]
-
[[Category: Cascio, D.]]
+
[[Category: Cascio D]]
-
[[Category: Colletier, J P.]]
+
[[Category: Colletier J-P]]
-
[[Category: Faham, S.]]
+
[[Category: Faham S]]
-
[[Category: Ping, P.]]
+
[[Category: Ping P]]
-
[[Category: Toro, L.]]
+
[[Category: Toro L]]
-
[[Category: Ujwal, R.]]
+
[[Category: Ujwal R]]
-
[[Category: Zhang, J.]]
+
[[Category: Zhang J]]
-
[[Category: Acetylation]]
+
-
[[Category: Alternative splicing]]
+
-
[[Category: Apoptosis]]
+
-
[[Category: Beta barrel]]
+
-
[[Category: Channel]]
+
-
[[Category: Eukaryotic membrane protein]]
+
-
[[Category: Ion transport]]
+
-
[[Category: Mitochondrion]]
+
-
[[Category: Outer membrane]]
+
-
[[Category: Phosphoprotein]]
+
-
[[Category: Porin]]
+
-
[[Category: Transmembrane]]
+
-
[[Category: Transport]]
+
-
[[Category: Vdac1]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 17 13:45:08 2008''
+

Current revision

The Crystal Structure of Mouse VDAC1 at 2.3 A resolution

PDB ID 3emn

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3emn"
Personal tools