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3fe3

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[[Image:3fe3.jpg|left|200px]]
 
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==Crystal structure of the kinase MARK3/Par-1: T211A-S215A double mutant==
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The line below this paragraph, containing "STRUCTURE_3fe3", creates the "Structure Box" on the page.
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<StructureSection load='3fe3' size='340' side='right'caption='[[3fe3]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3fe3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FE3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FE3 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fe3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fe3 OCA], [https://pdbe.org/3fe3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fe3 RCSB], [https://www.ebi.ac.uk/pdbsum/3fe3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fe3 ProSAT]</span></td></tr>
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{{STRUCTURE_3fe3| PDB=3fe3 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MARK3_HUMAN MARK3_HUMAN] Involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus.<ref>PMID:16980613</ref>
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===Crystal structure of the kinase MARK3/Par-1: T211A-S215A double mutant===
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==See Also==
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*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 16472737 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_16472737}}
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==About this Structure==
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3FE3 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FE3 OCA].
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==Reference==
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Structure of the catalytic and ubiquitin-associated domains of the protein kinase MARK/Par-1., Panneerselvam S, Marx A, Mandelkow EM, Mandelkow E, Structure. 2006 Feb;14(2):173-83. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16472737 16472737]
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Structural variations in the catalytic and ubiquitin-associated domains of microtubule-associated protein/microtubule affinity regulating kinase (MARK) 1 and MARK2., Marx A, Nugoor C, Muller J, Panneerselvam S, Timm T, Bilang M, Mylonas E, Svergun DI, Mandelkow EM, Mandelkow E, J Biol Chem. 2006 Sep 15;281(37):27586-99. Epub 2006 Jun 27. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16803889 16803889]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Large Structures]]
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[[Category: Mandelkow, E.]]
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[[Category: Mandelkow E]]
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[[Category: Mandelkow, E M.]]
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[[Category: Mandelkow E-M]]
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[[Category: Marx, A.]]
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[[Category: Marx A]]
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[[Category: Nugoor, C.]]
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[[Category: Nugoor C]]
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[[Category: Panneerselvam, S.]]
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[[Category: Panneerselvam S]]
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[[Category: Alternative splicing]]
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[[Category: Atp-binding]]
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[[Category: C-tak1]]
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[[Category: Kin1]]
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[[Category: Kinase]]
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[[Category: Mark]]
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[[Category: Mark3]]
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[[Category: Nucleotide-binding]]
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[[Category: P78]]
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[[Category: Par-1]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Serine/threonine protein kinase]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: Transferase]]
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[[Category: Uba domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 17 13:49:14 2008''
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Current revision

Crystal structure of the kinase MARK3/Par-1: T211A-S215A double mutant

PDB ID 3fe3

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