2w51

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'''Unreleased structure'''
 
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The entry 2w51 is ON HOLD until Paper Publication
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==Human mesencephalic astrocyte-derived neurotrophic factor (MANF)==
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<StructureSection load='2w51' size='340' side='right'caption='[[2w51]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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Authors: Parkash, V., Lindholm, P., Peranen, J., Kalkkinen, N., Oksanen, E., Saarma, M., Leppanen, V.M., Goldman, A.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2w51]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W51 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W51 FirstGlance]. <br>
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Description: Human mesencephalic astrocyte-derived neurotrophic factor (MANF)
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w51 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w51 OCA], [https://pdbe.org/2w51 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w51 RCSB], [https://www.ebi.ac.uk/pdbsum/2w51 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w51 ProSAT]</span></td></tr>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 24 11:24:54 2008''
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/MANF_HUMAN MANF_HUMAN] Familial pancreatic carcinoma.
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== Function ==
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[https://www.uniprot.org/uniprot/MANF_HUMAN MANF_HUMAN] Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death.<ref>PMID:12794311</ref> <ref>PMID:18561914</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w5/2w51_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w51 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Goldman A]]
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[[Category: Kalkkinen N]]
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[[Category: Leppanen VM]]
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[[Category: Lindholm P]]
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[[Category: Oksanen E]]
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[[Category: Parkash V]]
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[[Category: Peranen J]]
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[[Category: Saarma M]]

Current revision

Human mesencephalic astrocyte-derived neurotrophic factor (MANF)

PDB ID 2w51

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