2voe

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{{Seed}}
 
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[[Image:2voe.png|left|200px]]
 
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==Crystal structure of Rv2780 from M. tuberculosis H37Rv==
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The line below this paragraph, containing "STRUCTURE_2voe", creates the "Structure Box" on the page.
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<StructureSection load='2voe' size='340' side='right'caption='[[2voe]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2voe]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VOE FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2voe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2voe OCA], [https://pdbe.org/2voe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2voe RCSB], [https://www.ebi.ac.uk/pdbsum/2voe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2voe ProSAT]</span></td></tr>
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{{STRUCTURE_2voe| PDB=2voe | SCENE= }}
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</table>
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== Function ==
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===CRYSTAL STRUCTURE OF RV2780 FROM M. TUBERCULOSIS H37RV===
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[https://www.uniprot.org/uniprot/DHA_MYCTU DHA_MYCTU] Catalyzes the reversible reductive amination of pyruvate to L-alanine. However, since the physiological environment of M.tuberculosis has a neutral pH, it can be assumed that the enzyme catalyzes exclusively the formation of L-alanine. May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer.<ref>PMID:10527947</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
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Check<jmol>
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2VOE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOE OCA].
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vo/2voe_consurf.spt"</scriptWhenChecked>
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==Reference==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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Crystal structures of the Mycobacterium tuberculosis secretory antigen alanine dehydrogenase (Rv2780) in apo and ternary complex forms captures "open" and "closed" enzyme conformations., Tripathi SM, Ramachandran R, Proteins. 2008 Aug 15;72(3):1089-95. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18491387 18491387]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Alanine dehydrogenase]]
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</jmolCheckbox>
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[[Category: Mycobacterium tuberculosis]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2voe ConSurf].
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[[Category: Single protein]]
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<div style="clear:both"></div>
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[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
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== References ==
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[[Category: Alanine dehydrogenase]]
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<references/>
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[[Category: Nad]]
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__TOC__
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[[Category: Oxidoreductase]]
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</StructureSection>
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[[Category: Pyruvate]]
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[[Category: Large Structures]]
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[[Category: Rv2780]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Secreted]]
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[[Category: Ramachandran R]]
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[[Category: Tripathi SM]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 24 20:18:06 2008''
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Current revision

Crystal structure of Rv2780 from M. tuberculosis H37Rv

PDB ID 2voe

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