3eab

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{{Seed}}
 
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[[Image:3eab.png|left|200px]]
 
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==Crystal structure of Spastin MIT in complex with ESCRT III==
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The line below this paragraph, containing "STRUCTURE_3eab", creates the "Structure Box" on the page.
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<StructureSection load='3eab' size='340' side='right'caption='[[3eab]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3eab]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EAB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EAB FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eab FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eab OCA], [https://pdbe.org/3eab PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eab RCSB], [https://www.ebi.ac.uk/pdbsum/3eab PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eab ProSAT]</span></td></tr>
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{{STRUCTURE_3eab| PDB=3eab | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/SPAST_HUMAN SPAST_HUMAN] Defects in SPAST are the cause of spastic paraplegia autosomal dominant type 4 (SPG4) [MIM:[https://omim.org/entry/182601 182601]. Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG4 is the most common form of autosomal dominant spastic paraplegias.<ref>PMID:11809724</ref> <ref>PMID:15716377</ref> <ref>PMID:17389232</ref> <ref>PMID:19000169</ref> <ref>PMID:16339213</ref> <ref>PMID:15891913</ref> <ref>PMID:10610178</ref> <ref>PMID:11039577</ref> <ref>PMID:10699187</ref> <ref>PMID:11015453</ref> <ref>PMID:11087788</ref> <ref>PMID:11309678</ref> <ref>PMID:12460147</ref> <ref>PMID:11843700</ref> <ref>PMID:12124993</ref> <ref>PMID:12161613</ref> <ref>PMID:11985387</ref> <ref>PMID:12163196</ref> <ref>PMID:12202986</ref> <ref>PMID:12552568</ref> <ref>PMID:12939659</ref> <ref>PMID:14732620</ref> <ref>PMID:15210521</ref> <ref>PMID:15248095</ref> <ref>PMID:15482961</ref> <ref>PMID:15159500</ref> <ref>PMID:15326248</ref> <ref>PMID:16682546</ref> <ref>PMID:16684598</ref> <ref>PMID:17594340</ref> <ref>PMID:20214791</ref> <ref>PMID:20932283</ref> <ref>PMID:20562464</ref> <ref>PMID:20718791</ref> <ref>PMID:20550563</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/SPAST_HUMAN SPAST_HUMAN] ATP-dependent microtubule severing protein. Microtubule severing may promote reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and for completion of the abscission stage of cytokinesis. May also play a role in axon growth and the formation of axonal branches.<ref>PMID:11809724</ref> <ref>PMID:12676568</ref> <ref>PMID:15716377</ref> <ref>PMID:16219033</ref> <ref>PMID:17389232</ref> <ref>PMID:19000169</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ea/3eab_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3eab ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of Spastin MIT in complex with ESCRT III===
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==See Also==
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*[[Charged multivesicular body protein 3D structures|Charged multivesicular body protein 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_18997780}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 18997780 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_18997780}}
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==About this Structure==
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3EAB is a 12 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EAB OCA].
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==Reference==
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Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B., Yang D, Rismanchi N, Renvoise B, Lippincott-Schwartz J, Blackstone C, Hurley JH, Nat Struct Mol Biol. 2008 Dec;15(12):1278-86. Epub 2008 Nov 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18997780 18997780]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Blackstone, C.]]
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[[Category: Large Structures]]
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[[Category: Hurley, J H.]]
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[[Category: Blackstone C]]
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[[Category: Lippincott-Schwartz, J.]]
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[[Category: Hurley JH]]
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[[Category: Renvoise, B.]]
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[[Category: Lippincott-Schwartz J]]
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[[Category: Rimanchi, N.]]
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[[Category: Renvoise B]]
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[[Category: Yang, D.]]
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[[Category: Rimanchi N]]
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[[Category: Alternative splicing]]
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[[Category: Yang D]]
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[[Category: Atp-binding]]
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[[Category: Cell cycle]]
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[[Category: Chmp]]
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[[Category: Cytoplasm]]
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[[Category: Disease mutation]]
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[[Category: Escrt]]
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[[Category: Hereditary spastic paraplegia]]
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[[Category: Mit]]
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[[Category: Nucleotide-binding]]
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[[Category: Nucleus]]
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[[Category: Polymorphism]]
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[[Category: Spastin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 31 09:03:36 2008''
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Current revision

Crystal structure of Spastin MIT in complex with ESCRT III

PDB ID 3eab

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