2io4

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{{Seed}}
 
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[[Image:2io4.png|left|200px]]
 
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==Crystal structure of PCNA12 dimer from Sulfolobus solfataricus.==
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The line below this paragraph, containing "STRUCTURE_2io4", creates the "Structure Box" on the page.
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<StructureSection load='2io4' size='340' side='right'caption='[[2io4]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2io4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus_P2 Saccharolobus solfataricus P2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IO4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IO4 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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{{STRUCTURE_2io4| PDB=2io4 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2io4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2io4 OCA], [https://pdbe.org/2io4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2io4 RCSB], [https://www.ebi.ac.uk/pdbsum/2io4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2io4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PCNA1_SACS2 PCNA1_SACS2] One of the sliding clamp subunits that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. Heterotrimer stimulates the Holliday junction resolvase Hjc. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation.<ref>PMID:12535540</ref> <ref>PMID:17011573</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/io/2io4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2io4 ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of PCNA12 dimer from Sulfolobus solfataricus.===
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==See Also==
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*[[Proliferating cell nuclear antigen 3D structures|Proliferating cell nuclear antigen 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 18703842 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_18703842}}
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[[Category: Saccharolobus solfataricus P2]]
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[[Category: Hlinkova V]]
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==About this Structure==
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[[Category: Ling H]]
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2IO4 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus_p2 Sulfolobus solfataricus p2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IO4 OCA].
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==Reference==
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Structures of monomeric, dimeric and trimeric PCNA: PCNA-ring assembly and opening., Hlinkova V, Xing G, Bauer J, Shin YJ, Dionne I, Rajashankar KR, Bell SD, Ling H, Acta Crystallogr D Biol Crystallogr. 2008 Sep;64(Pt 9):941-9. Epub 2008, Aug 13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18703842 18703842]
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[[Category: Sulfolobus solfataricus p2]]
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[[Category: Hlinkova, V.]]
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[[Category: Ling, H.]]
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[[Category: Dna binding protein]]
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[[Category: Pcna12 heterodimer]]
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[[Category: Pcna123 heterotrimer]]
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[[Category: Protein-protein interaction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 31 09:05:18 2008''
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Current revision

Crystal structure of PCNA12 dimer from Sulfolobus solfataricus.

PDB ID 2io4

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