3chn

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{{Seed}}
 
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[[Image:3chn.jpg|left|200px]]
 
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<!--
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==Solution structure of human secretory IgA1==
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The line below this paragraph, containing "STRUCTURE_3chn", creates the "Structure Box" on the page.
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<StructureSection load='3chn' size='340' side='right'caption='[[3chn]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3chn]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CHN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CHN FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray solution scattering</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3chn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3chn OCA], [https://pdbe.org/3chn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3chn RCSB], [https://www.ebi.ac.uk/pdbsum/3chn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3chn ProSAT]</span></td></tr>
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{{STRUCTURE_3chn| PDB=3chn | SCENE= }}
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</table>
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== Disease ==
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===Solution structure of human secretory IgA1===
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[https://www.uniprot.org/uniprot/IGHA1_HUMAN IGHA1_HUMAN] Note=A chromosomal aberration involving IGHA1 is found in multiple myeloma (MM) cell lines. Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein.
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== Function ==
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[https://www.uniprot.org/uniprot/IGHA1_HUMAN IGHA1_HUMAN] Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system.
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== Evolutionary Conservation ==
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The line below this paragraph, {{ABSTRACT_PUBMED_19079336}}, adds the Publication Abstract to the page
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[[Image:Consurf_key_small.gif|200px|right]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19079336 is the PubMed ID number.
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Check<jmol>
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<jmolCheckbox>
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{{ABSTRACT_PUBMED_19079336}}
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ch/3chn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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==About this Structure==
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<text>to colour the structure by Evolutionary Conservation</text>
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3CHN is a 10 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CHN OCA].
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3chn ConSurf].
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==Reference==
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<div style="clear:both"></div>
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Location of secretory component on the Fc edge of dimeric IgA1 reveals insight into the role of secretory IgA1 in mucosal immunity., Bonner A, Almogren A, Furtado PB, Kerr MA, Perkins SJ, Mucosal Immunol. 2009 Jan;2(1):74-84. Epub 2008 Oct 8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/19079336 19079336]
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Almogren, A.]]
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[[Category: Large Structures]]
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[[Category: Bonner, A.]]
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[[Category: Almogren A]]
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[[Category: Furtado, P B.]]
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[[Category: Bonner A]]
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[[Category: Kerr, M A.]]
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[[Category: Furtado PB]]
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[[Category: Perkins, S J.]]
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[[Category: Kerr MA]]
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[[Category: Chromophore]]
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[[Category: Perkins SJ]]
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[[Category: Glycoprotein]]
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[[Category: Immune system]]
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[[Category: Immunoglobulin some]]
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[[Category: Immunoglobulin c region]]
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[[Category: Immunoglobulin domain]]
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[[Category: Membrane]]
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[[Category: Mucosal immunity]]
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[[Category: Neutron scattering]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Secreted]]
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[[Category: Secretory immunoglobulin some]]
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[[Category: Transmembrane]]
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[[Category: X-ray scattering]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 31 10:22:04 2008''
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Current revision

Solution structure of human secretory IgA1

PDB ID 3chn

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Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3chn"
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