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3fia

From Proteopedia

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{{Seed}}
 
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[[Image:3fia.jpg|left|200px]]
 
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<!--
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==Crystal structure of the EH 1 domain from human intersectin-1 protein. Northeast Structural Genomics Consortium target HR3646e.==
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The line below this paragraph, containing "STRUCTURE_3fia", creates the "Structure Box" on the page.
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<StructureSection load='3fia' size='340' side='right'caption='[[3fia]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3fia]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FIA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FIA FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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-->
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_3fia| PDB=3fia | SCENE= }}
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ITSN, ITSN1, SH3D1A ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fia OCA], [https://pdbe.org/3fia PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fia RCSB], [https://www.ebi.ac.uk/pdbsum/3fia PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fia ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/ITSN1_HUMAN ITSN1_HUMAN]] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.<ref>PMID:11744688</ref> <ref>PMID:22648170</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fi/3fia_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fia ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of the EH 1 domain from human intersectin-1 protein. Northeast Structural Genomics Consortium target HR3646e.===
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==See Also==
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*[[Intersectin|Intersectin]]
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== References ==
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==About this Structure==
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<references/>
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3FIA is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FIA OCA].
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__TOC__
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[[Category: Homo sapiens]]
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</StructureSection>
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[[Category: Acton, T B.]]
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[[Category: Human]]
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[[Category: Chen, Y.]]
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[[Category: Large Structures]]
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[[Category: Ciccosanti, C.]]
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[[Category: Acton, T B]]
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[[Category: Devices, C.]]
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[[Category: Chen, Y]]
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[[Category: Foote, E L.]]
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[[Category: Ciccosanti, C]]
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[[Category: Hunt, J F.]]
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[[Category: Devices, C]]
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[[Category: Mao,L.]]
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[[Category: Foote, E L]]
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[[Category: Montelione, G T.]]
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[[Category: Hunt, J F]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Mao, L]]
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[[Category: Seetharaman, J.]]
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[[Category: Montelione, G T]]
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[[Category: Tong, L.]]
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[[Category: Structural genomic]]
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[[Category: Vorobiev, S M.]]
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[[Category: Seetharaman, J]]
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[[Category: Xiao, R.]]
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[[Category: Tong, L]]
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[[Category: Zhao, L.]]
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[[Category: Vorobiev, S M]]
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[[Category: Xiao, R]]
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[[Category: Zhao, L]]
[[Category: Alternative splicing]]
[[Category: Alternative splicing]]
[[Category: Calcium]]
[[Category: Calcium]]
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[[Category: Membrane]]
[[Category: Membrane]]
[[Category: Nesg]]
[[Category: Nesg]]
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[[Category: Northeast structural genomics consortium]]
 
[[Category: Phosphoprotein]]
[[Category: Phosphoprotein]]
[[Category: Protein binding]]
[[Category: Protein binding]]
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[[Category: Protein structure initiative]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Psi-2]]
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[[Category: Sh3 domain]]
[[Category: Sh3 domain]]
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[[Category: Structural genomic]]
 
[[Category: Synapse]]
[[Category: Synapse]]
[[Category: Synaptosome]]
[[Category: Synaptosome]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 31 10:40:07 2008''
 

Current revision

Crystal structure of the EH 1 domain from human intersectin-1 protein. Northeast Structural Genomics Consortium target HR3646e.

PDB ID 3fia

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