1zr9

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{{Seed}}
 
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[[Image:1zr9.png|left|200px]]
 
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==Solution Structure of a Human C2H2-type Zinc Finger Protein==
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The line below this paragraph, containing "STRUCTURE_1zr9", creates the "Structure Box" on the page.
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<StructureSection load='1zr9' size='340' side='right'caption='[[1zr9]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1zr9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZR9 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1zr9| PDB=1zr9 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zr9 OCA], [https://pdbe.org/1zr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zr9 RCSB], [https://www.ebi.ac.uk/pdbsum/1zr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zr9 ProSAT], [https://www.topsan.org/Proteins/CESG/1zr9 TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ZN593_HUMAN ZN593_HUMAN] Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity. Could act either by binding to DNA octamer or by interacting with Oct-2. May also be a modulator of other octamer-binding proteins.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zr/1zr9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zr9 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Here, we report the solution structure of ZNF593, a protein identified in a functional study as a negative modulator of the DNA-binding activity of the Oct-2 transcription factor. ZNF593 contains a classic C(2)H(2) zinc finger domain flanked by about 40 disordered residues on each terminus. Although the protein contains a high degree of intrinsic disorder, the structure of the zinc finger domain was resolved by NMR spectroscopy without a need for N- or C-terminal truncations. The tertiary structure of the zinc finger domain is composed of a beta-hairpin that positions the cysteine side chains for zinc coordination, followed by an atypical kinked alpha-helix containing the two histidine side chain ligands. The structural topology of ZNF593 is similar to a fragment of the double-stranded RNA-binding protein Zfa and the C-terminal zinc finger of MBP-1, a human enhancer binding protein. The structure presented here will provide a guide for future functional studies of how ZNF593 negatively modulates the DNA-binding activity of Oct-2, a POU domain-containing transcription factor. Our work illustrates the unique capacity of NMR spectroscopy for structural analysis of folded domains in a predominantly disordered protein.
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===Solution Structure of a Human C2H2-type Zinc Finger Protein===
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The solution structure of ZNF593 from Homo sapiens reveals a zinc finger in a predominantly unstructured protein.,Hayes PL, Lytle BL, Volkman BF, Peterson FC Protein Sci. 2008 Mar;17(3):571-6. PMID:18287285<ref>PMID:18287285</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_18287285}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1zr9" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 18287285 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18287285}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1ZR9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZR9 OCA].
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==Reference==
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The solution structure of ZNF593 from Homo sapiens reveals a zinc finger in a predominantly unstructured protein., Hayes PL, Lytle BL, Volkman BF, Peterson FC, Protein Sci. 2008 Mar;17(3):571-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18287285 18287285]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
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[[Category: Lytle BL]]
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[[Category: Center for eukaryotic structural genomic]]
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[[Category: Peterson FC]]
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[[Category: Cesg]]
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[[Category: Volkman BF]]
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[[Category: Dna binding]]
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[[Category: Protein structure initiative]]
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[[Category: Psi]]
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[[Category: Structural genomic]]
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[[Category: Transcription]]
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[[Category: Zinc finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 31 20:21:05 2008''
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Current revision

Solution Structure of a Human C2H2-type Zinc Finger Protein

PDB ID 1zr9

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