2pqa

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{{Seed}}
 
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[[Image:2pqa.png|left|200px]]
 
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==Crystal Structure of Full-length Human RPA 14/32 Heterodimer==
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The line below this paragraph, containing "STRUCTURE_2pqa", creates the "Structure Box" on the page.
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<StructureSection load='2pqa' size='340' side='right'caption='[[2pqa]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2pqa]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PQA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PQA FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pqa OCA], [https://pdbe.org/2pqa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pqa RCSB], [https://www.ebi.ac.uk/pdbsum/2pqa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pqa ProSAT]</span></td></tr>
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{{STRUCTURE_2pqa| PDB=2pqa | SCENE= }}
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</table>
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== Function ==
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===Crystal Structure of Full-length Human RPA 14/32 Heterodimer===
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[https://www.uniprot.org/uniprot/RFA2_HUMAN RFA2_HUMAN] Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions. Required for the efficient recruitment of the DNA double-strand break repair factor RAD51 to chromatin in response to DNA damage.<ref>PMID:15205463</ref> <ref>PMID:19116208</ref> <ref>PMID:19996105</ref> <ref>PMID:20154705</ref> Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.<ref>PMID:15205463</ref> <ref>PMID:19116208</ref> <ref>PMID:19996105</ref> <ref>PMID:20154705</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 17976647 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pq/2pqa_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_17976647}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pqa ConSurf].
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2PQA is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PQA OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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Structure of the full-length human RPA14/32 complex gives insights into the mechanism of DNA binding and complex formation., Deng X, Habel JE, Kabaleeswaran V, Snell EH, Wold MS, Borgstahl GE, J Mol Biol. 2007 Dec 7;374(4):865-76. Epub 2007 Oct 2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17976647 17976647]
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Borgstahl, G E.]]
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[[Category: Large Structures]]
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[[Category: Deng, X.]]
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[[Category: Borgstahl GE]]
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[[Category: Ob-fold]]
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[[Category: Deng X]]
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[[Category: Replication]]
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[[Category: Rpa14/32]]
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[[Category: Ssdna binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 7 08:10:38 2009''
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Current revision

Crystal Structure of Full-length Human RPA 14/32 Heterodimer

PDB ID 2pqa

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