3da6

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[[Image:3da6.jpg|left|200px]]
 
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==Crystal Structure of human JNK3 complexed with N-(3-methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)naphthalen-1-yl)-1H-benzo[d]imidazol-2-amine==
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The line below this paragraph, containing "STRUCTURE_3da6", creates the "Structure Box" on the page.
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<StructureSection load='3da6' size='340' side='right'caption='[[3da6]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3da6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DA6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DA6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BZ9:N-[3-METHYL-4-({3-[2-(METHYLAMINO)PYRIMIDIN-4-YL]PYRIDIN-2-YL}OXY)NAPHTHALEN-1-YL]-1H-BENZIMIDAZOL-2-AMINE'>BZ9</scene></td></tr>
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{{STRUCTURE_3da6| PDB=3da6 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3da6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3da6 OCA], [https://pdbe.org/3da6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3da6 RCSB], [https://www.ebi.ac.uk/pdbsum/3da6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3da6 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/MK10_HUMAN MK10_HUMAN] Defects in MAPK10 are a cause of epileptic encephalopathy Lennox-Gastaut type (EELG) [MIM:[https://omim.org/entry/606369 606369]. Epileptic encephalopathies of the Lennox-Gastaut group are childhood epileptic disorders characterized by severe psychomotor delay and seizures. Note=A chromosomal aberration involving MAPK10 has been found in a single patient. Translocation t(Y;4)(q11.2;q21) which causes MAPK10 truncation.
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== Function ==
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[https://www.uniprot.org/uniprot/MK10_HUMAN MK10_HUMAN] Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons.<ref>PMID:11718727</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/da/3da6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3da6 ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of human JNK3 complexed with N-(3-methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)naphthalen-1-yl)-1H-benzo[d]imidazol-2-amine===
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==See Also==
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*[[Mitogen-activated protein kinase 3D structures|Mitogen-activated protein kinase 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_19062275}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 19062275 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_19062275}}
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==About this Structure==
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3DA6 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DA6 OCA].
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==Reference==
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Pyridyl-pyrimidine benzimidazole derivatives as potent, selective, and orally bioavailable inhibitors of Tie-2 kinase., Cee VJ, Cheng AC, Romero K, Bellon S, Mohr C, Whittington DA, Bak A, Bready J, Caenepeel S, Coxon A, Deak HL, Fretland J, Gu Y, Hodous BL, Huang X, Kim JL, Lin J, Long AM, Nguyen H, Olivieri PR, Patel VF, Wang L, Zhou Y, Hughes P, Geuns-Meyer S, Bioorg Med Chem Lett. 2008 Nov 20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/19062275 19062275]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Mitogen-activated protein kinase]]
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[[Category: Large Structures]]
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[[Category: Bellon, S.]]
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[[Category: Bellon S]]
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[[Category: Bready, J.]]
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[[Category: Bready J]]
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[[Category: Caenepeel, S.]]
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[[Category: Caenepeel S]]
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[[Category: Cee, V J.]]
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[[Category: Cee VJ]]
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[[Category: Cheng, A C.]]
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[[Category: Cheng AC]]
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[[Category: Coxon, A.]]
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[[Category: Coxon A]]
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[[Category: Deak, H L.]]
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[[Category: Deak HL]]
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[[Category: Geuns-Meyer, S.]]
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[[Category: Geuns-Meyer S]]
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[[Category: Hodous, B L.]]
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[[Category: Hodous BL]]
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[[Category: Hughes, P.]]
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[[Category: Hughes P]]
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[[Category: Kim, J L.]]
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[[Category: Kim JL]]
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[[Category: Lin, J.]]
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[[Category: Lin J]]
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[[Category: Mohr, C.]]
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[[Category: Mohr C]]
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[[Category: Nguyen, H.]]
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[[Category: Nguyen H]]
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[[Category: Olivieri, P R.]]
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[[Category: Olivieri PR]]
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[[Category: Patel, V F.]]
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[[Category: Patel VF]]
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[[Category: Romero, K.]]
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[[Category: Romero K]]
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[[Category: Wang, L.]]
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[[Category: Wang L]]
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[[Category: Whittington, D A.]]
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[[Category: Whittington DA]]
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[[Category: Alternative splicing]]
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[[Category: Atp-binding]]
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[[Category: Chromosomal rearrangement]]
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[[Category: Cytoplasm]]
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[[Category: Epilepsy]]
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[[Category: Jnk3]]
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[[Category: Kinase]]
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[[Category: Nucleotide-binding]]
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[[Category: Phosphoprotein]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 7 09:45:11 2009''
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Current revision

Crystal Structure of human JNK3 complexed with N-(3-methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)naphthalen-1-yl)-1H-benzo[d]imidazol-2-amine

PDB ID 3da6

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