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C-di-GMP

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Cyclic di-GMP, (bis-(3'-5') cyclic diguanylic acid)
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<applet load='2v0n' scene='C-di-GMP/C-di-gmp/1' size='400' frame='true' align='right' caption='cyclic di-GMP, as found in complex with the diguanylate cyclase PleD [[2v0n]]' />
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[http://www.uniprot.org/keywords/973 "UNIPROT link"]
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Cyclic di-GMP, (bis-(3'-5') cyclic diguanylic acid)<br><br>
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C-di-GMP is a second messenger that mediates the regulation of cell-surface associated traits in bacteria.
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<scene name='C-di-GMP/C-di-gmp/3'>C-di-GMP</scene>
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is a cyclic dinucleotide with a 12-membered macro-cycle composed of the the phosphate and ribose moieties. It tends to associate to form <scene name='C-di-GMP/C-di-gmp/4'>dimers</scene> with intercalated, stacked bases.
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Several protein structures involved in c-di-GMP signaling have been determined (see [[C-di-GMP signaling]]).
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<br><br>
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[http://www.uniprot.org/keywords/973 UNIPROT link]
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<br><br><br><br><br><br><br><br>
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<br><br>
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==References==
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Reviews:
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<ref group="xtra">PMID:2158107</ref><ref group="xtra">PMID: 8286055 </ref>
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<references group="xtra"/>
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[[Category: C-di-GMP]]

Current revision

cyclic di-GMP, as found in complex with the diguanylate cyclase PleD 2v0n

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Cyclic di-GMP, (bis-(3'-5') cyclic diguanylic acid)


C-di-GMP is a second messenger that mediates the regulation of cell-surface associated traits in bacteria.

is a cyclic dinucleotide with a 12-membered macro-cycle composed of the the phosphate and ribose moieties. It tends to associate to form with intercalated, stacked bases.


Several protein structures involved in c-di-GMP signaling have been determined (see C-di-GMP signaling).



UNIPROT link









References

Reviews:

  • Egli M, Gessner RV, Williams LD, Quigley GJ, van der Marel GA, van Boom JH, Rich A, Frederick CA. Atomic-resolution structure of the cellulose synthase regulator cyclic diguanylic acid. Proc Natl Acad Sci U S A. 1990 Apr;87(8):3235-9. PMID:2158107
  • Guan Y, Gao YG, Liaw YC, Robinson H, Wang AH. Molecular structure of cyclic diguanylic acid at 1 A resolution of two crystal forms: self-association, interactions with metal ion/planar dyes and modeling studies. J Biomol Struct Dyn. 1993 Oct;11(2):253-76. PMID:8286055

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Tilman Schirmer

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