3fr5
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3fr5 is ON HOLD Authors: Barf, T., Hammer, K., Lehmann, F., Haile, S., Axen, E., Medina, C., Uppenberg, J., Svensson, S., Rondahl, L., Lundb ck, T. ...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte Fatty-Acid Binding Protein (A-FABP) inhibitors== | |
| + | <StructureSection load='3fr5' size='340' side='right'caption='[[3fr5]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3fr5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FR5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FR5 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I4A:5-(3-CARBAMOYLBENZYL)-5,6,7,8,9,10-HEXAHYDROCYCLOHEPTA[B]INDOLE-4-CARBOXYLIC+ACID'>I4A</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fr5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fr5 OCA], [https://pdbe.org/3fr5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fr5 RCSB], [https://www.ebi.ac.uk/pdbsum/3fr5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fr5 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/FABP4_HUMAN FABP4_HUMAN] Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity). | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fr/3fr5_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fr5 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | + | ==See Also== | |
| - | + | *[[Fatty acid-binding protein 3D structures|Fatty acid-binding protein 3D structures]] | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Homo sapiens]] | |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Axen E]] | ||
| + | [[Category: Barf T]] | ||
| + | [[Category: Haile S]] | ||
| + | [[Category: Hammer K]] | ||
| + | [[Category: Lehmann F]] | ||
| + | [[Category: Lundb ck T]] | ||
| + | [[Category: Medina C]] | ||
| + | [[Category: Rondahl L]] | ||
| + | [[Category: Svensson S]] | ||
| + | [[Category: Uppenberg J]] | ||
Current revision
N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte Fatty-Acid Binding Protein (A-FABP) inhibitors
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Categories: Homo sapiens | Large Structures | Axen E | Barf T | Haile S | Hammer K | Lehmann F | Lundb ck T | Medina C | Rondahl L | Svensson S | Uppenberg J
