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| - | [[Image:1we3.jpg|left|200px]]<br /><applet load="1we3" size="450" color="white" frame="true" align="right" spinBox="true" | + | #REDIRECT [[4v4o]] This PDB entry is obsolete and replaced by 4v4o |
| - | caption="1we3, resolution 2.80Å" />
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| - | '''Crystal Structure of the Chaperonin Complex Cpn60/Cpn10/(ADP)7 from Thermus Thermophilus'''<br />
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| - | ==Overview==
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| - | The chaperonins GroEL and GroES are essential mediators of protein, folding. GroEL binds nonnative protein, ATP, and GroES, generating a, ternary complex in which protein folding occurs within the cavity capped, by GroES (cis-cavity). We determined the crystal structure of the native, GroEL-GroES-ADP homolog from Thermus thermophilus, with substrate proteins, in the cis-cavity, at 2.8 A resolution. Twenty-four in vivo substrate, proteins within the cis-cavity were identified from the crystals. The, structure around the cis-cavity, which encapsulates substrate proteins, shows significant differences from that observed for the substrate-free, Escherichia coli GroEL-GroES complex. The apical domain around the, cis-cavity of the Thermus GroEL-GroES complex exhibits a large deviation, from the 7-fold symmetry. As a result, the GroEL-GroES interface differs, considerably from the previously reported E. coli GroEL-GroES complex, including a previously unknown contact between GroEL and GroES.
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| - | ==About this Structure==
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| - | 1WE3 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus] with MG, ADP and DMS as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1WE3 OCA].
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| - | ==Reference==
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| - | Crystal structure of the native chaperonin complex from Thermus thermophilus revealed unexpected asymmetry at the cis-cavity., Shimamura T, Koike-Takeshita A, Yokoyama K, Masui R, Murai N, Yoshida M, Taguchi H, Iwata S, Structure. 2004 Aug;12(8):1471-80. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15296740 15296740]
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| - | [[Category: Protein complex]]
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| - | [[Category: Thermus thermophilus]]
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| - | [[Category: Iwata, S.]]
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| - | [[Category: Koike-Takeshita, A.]]
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| - | [[Category: Masui, R.]]
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| - | [[Category: Murai, N.]]
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| - | [[Category: Shimamura, T.]]
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| - | [[Category: Taguchi, H.]]
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| - | [[Category: Yokoyama, K.]]
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| - | [[Category: Yoshida, M.]]
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| - | [[Category: ADP]]
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| - | [[Category: DMS]]
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| - | [[Category: MG]]
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| - | [[Category: adp]]
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| - | [[Category: atp]]
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| - | [[Category: chaperone]]
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| - | [[Category: chaperonin]]
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| - | [[Category: cpn10]]
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| - | [[Category: cpn60]]
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| - | [[Category: folding]]
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| - | [[Category: groel]]
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| - | [[Category: groes]]
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| - | [[Category: hsp10]]
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| - | [[Category: hsp60]]
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| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 05:20:24 2007''
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