3e7t

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{{Seed}}
 
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[[Image:3e7t.png|left|200px]]
 
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==Structure of murine iNOS oxygenase domain with inhibitor AR-C102222==
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The line below this paragraph, containing "STRUCTURE_3e7t", creates the "Structure Box" on the page.
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<StructureSection load='3e7t' size='340' side='right'caption='[[3e7t]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3e7t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. The January 2011 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Nitric Oxide Synthase'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2011_1 10.2210/rcsb_pdb/mom_2011_1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E7T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E7T FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B14:1-(6-CYANO-3-PYRIDYLCARBONYL)-5,8-DIFLUOROSPIRO[PIPERIDINE-4,2(1H)-QUINAZOLINE]-4-AMINE'>B14</scene>, <scene name='pdbligand=HBI:7,8-DIHYDROBIOPTERIN'>HBI</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3e7t| PDB=3e7t | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e7t OCA], [https://pdbe.org/3e7t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e7t RCSB], [https://www.ebi.ac.uk/pdbsum/3e7t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e7t ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.<ref>PMID:16373578</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e7/3e7t_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e7t ConSurf].
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<div style="clear:both"></div>
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===Structure of murine iNOS oxygenase domain with inhibitor AR-C102222===
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==See Also==
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*[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 18849972 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_18849972}}
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==About this Structure==
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3E7T is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E7T OCA].
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==Reference==
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Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase., Garcin ED, Arvai AS, Rosenfeld RJ, Kroeger MD, Crane BR, Andersson G, Andrews G, Hamley PJ, Mallinder PR, Nicholls DJ, St-Gallay SA, Tinker AC, Gensmantel NP, Mete A, Cheshire DR, Connolly S, Stuehr DJ, Aberg A, Wallace AV, Tainer JA, Getzoff ED, Nat Chem Biol. 2008 Nov;4(11):700-7. Epub 2008 Oct 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18849972 18849972]
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Nitric-oxide synthase]]
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[[Category: Nitric Oxide Synthase]]
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[[Category: Single protein]]
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[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
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[[Category: Aberg A]]
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[[Category: Fad]]
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[[Category: Andersson G]]
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[[Category: Fmn]]
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[[Category: Andrews G]]
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[[Category: Heme]]
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[[Category: Arvai AS]]
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[[Category: Iron]]
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[[Category: Cheshire DR]]
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[[Category: Metal-binding]]
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[[Category: Connolly S]]
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[[Category: Nadp]]
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[[Category: Crane BR]]
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[[Category: Nitric oxide synthase]]
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[[Category: Garcin ED]]
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[[Category: No]]
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[[Category: Gensmantel NP]]
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[[Category: Oxidoreductase]]
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[[Category: Getzoff ED]]
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[[Category: Oxidoreductase calmodulin-binding]]
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[[Category: Hamley PJ]]
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[[Category: Polymorphism]]
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[[Category: Kroeger MD]]
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[[Category: Tetrahydrobiopterin]]
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[[Category: Mallinder PR]]
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[[Category: Zinc]]
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[[Category: Mete A]]
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[[Category: Nicholls DJ]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 14 20:19:52 2009''
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[[Category: Rosenfeld RJ]]
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[[Category: St-Gallay SA]]
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[[Category: Stuehr DJ]]
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[[Category: Tainer JA]]
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[[Category: Tinker AC]]
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[[Category: Wallace AV]]

Current revision

Structure of murine iNOS oxygenase domain with inhibitor AR-C102222

PDB ID 3e7t

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