3ej8

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{{Seed}}
 
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[[Image:3ej8.png|left|200px]]
 
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==Structure of double mutant of human iNOS oxygenase domain with bound immidazole==
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The line below this paragraph, containing "STRUCTURE_3ej8", creates the "Structure Box" on the page.
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<StructureSection load='3ej8' size='340' side='right'caption='[[3ej8]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ej8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EJ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EJ8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3ej8| PDB=3ej8 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ej8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ej8 OCA], [https://pdbe.org/3ej8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ej8 RCSB], [https://www.ebi.ac.uk/pdbsum/3ej8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ej8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NOS2_HUMAN NOS2_HUMAN] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ej/3ej8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ej8 ConSurf].
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<div style="clear:both"></div>
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===Structure of double mutant of human iNOS oxygenase domain with bound immidazole===
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==See Also==
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*[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]]
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__TOC__
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 18849972 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18849972}}
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==About this Structure==
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3EJ8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EJ8 OCA].
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==Reference==
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Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase., Garcin ED, Arvai AS, Rosenfeld RJ, Kroeger MD, Crane BR, Andersson G, Andrews G, Hamley PJ, Mallinder PR, Nicholls DJ, St-Gallay SA, Tinker AC, Gensmantel NP, Mete A, Cheshire DR, Connolly S, Stuehr DJ, Aberg A, Wallace AV, Tainer JA, Getzoff ED, Nat Chem Biol. 2008 Nov;4(11):700-7. Epub 2008 Oct 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18849972 18849972]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Nitric-oxide synthase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Aberg A]]
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[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
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[[Category: Andersson G]]
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[[Category: Fad]]
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[[Category: Andrews G]]
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[[Category: Fmn]]
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[[Category: Arvai AS]]
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[[Category: Heme]]
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[[Category: Cheshire DR]]
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[[Category: Iron]]
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[[Category: Connolly S]]
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[[Category: Metal-binding]]
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[[Category: Crane BR]]
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[[Category: Nadp]]
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[[Category: Garcin ED]]
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[[Category: Nitric oxide synthase]]
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[[Category: Gensmantel NP]]
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[[Category: No]]
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[[Category: Getzoff ED]]
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[[Category: Oxidoreductase]]
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[[Category: Hamley PJ]]
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[[Category: Oxidoreductase calmodulin-binding]]
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[[Category: Kroeger MD]]
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[[Category: Polymorphism]]
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[[Category: Mallinder PR]]
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[[Category: Tetrahydrobiopterin]]
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[[Category: Mete A]]
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[[Category: Zinc]]
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[[Category: Nicholls DJ]]
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[[Category: Rosenfeld RJ]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 14 20:34:18 2009''
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[[Category: St-Gallay SA]]
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[[Category: Stuehr DJ]]
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[[Category: Tainer JA]]
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[[Category: Tinker AC]]
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[[Category: Wallace AV]]

Current revision

Structure of double mutant of human iNOS oxygenase domain with bound immidazole

PDB ID 3ej8

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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