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2w86
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 2w86 is ON HOLD until Paper Publication Authors: Jensen, S.A., Iqbal, S., Lowe, E.D., Redfield, C., Handford, P.A. Description: Crystal structure o...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of fibrillin-1 domains cbEGF9hyb2cbEGF10, calcium saturated form== | |
| + | <StructureSection load='2w86' size='340' side='right'caption='[[2w86]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2w86]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W86 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W86 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1uzk|1uzk]], [[1uzj|1uzj]], [[1uzp|1uzp]], [[1apj|1apj]], [[1uzq|1uzq]], [[1lmj|1lmj]]</div></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w86 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w86 OCA], [https://pdbe.org/2w86 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w86 RCSB], [https://www.ebi.ac.uk/pdbsum/2w86 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w86 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w8/2w86_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w86 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The fibrillins and latent transforming growth factor-beta binding proteins (LTBPs) form a superfamily of structurally-related proteins consisting of calcium-binding epidermal growth factor-like (cbEGF) domains interspersed with 8-cysteine-containing transforming growth factor beta-binding protein-like (TB) and hybrid (hyb) domains. Fibrillins are the major components of the extracellular 10-12 nm diameter microfibrils, which mediate a variety of cell-matrix interactions. Here we present the crystal structure of a fibrillin-1 cbEGF9-hyb2-cbEGF10 fragment, solved to 1.8 A resolution. The hybrid domain fold is similar, but not identical, to the TB domain fold seen in previous fibrillin-1 and LTBP-1 fragments. Pairwise interactions with neighboring cbEGF domains demonstrate extensive interfaces, with the hyb2-cbEGF10 interface dependent on Ca(2+) binding. These observations provide accurate constraints for models of fibrillin organization within the 10-12 nm microfibrils and provide further molecular insights into how Ca(2+) binding influences the intermolecular interactions and biomechanical properties of fibrillin-1. | ||
| - | + | Structure and interdomain interactions of a hybrid domain: a disulphide-rich module of the fibrillin/LTBP superfamily of matrix proteins.,Jensen SA, Iqbal S, Lowe ED, Redfield C, Handford PA Structure. 2009 May 13;17(5):759-68. PMID:19446531<ref>PMID:19446531</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 2w86" style="background-color:#fffaf0;"></div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Handford, P A]] | ||
| + | [[Category: Iqbal, S]] | ||
| + | [[Category: Jensen, S A]] | ||
| + | [[Category: Lowe, E D]] | ||
| + | [[Category: Redfield, C]] | ||
| + | [[Category: Calcium]] | ||
| + | [[Category: Craniosynostosis]] | ||
| + | [[Category: Disease mutation]] | ||
| + | [[Category: Egf-like domain]] | ||
| + | [[Category: Extracellular matrix]] | ||
| + | [[Category: Fibrillin]] | ||
| + | [[Category: Fibrillin calcium cbegf hybrid]] | ||
| + | [[Category: Glycoprotein]] | ||
| + | [[Category: Phosphoprotein]] | ||
| + | [[Category: Polymorphism]] | ||
| + | [[Category: Secreted]] | ||
Current revision
Crystal structure of fibrillin-1 domains cbEGF9hyb2cbEGF10, calcium saturated form
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