1whd

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(New page: 200px<br /><applet load="1whd" size="450" color="white" frame="true" align="right" spinBox="true" caption="1whd" /> '''Solution structure of the PDZ domain of RGS3...)
Current revision (13:39, 9 May 2024) (edit) (undo)
 
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[[Image:1whd.gif|left|200px]]<br /><applet load="1whd" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1whd" />
 
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'''Solution structure of the PDZ domain of RGS3'''<br />
 
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==About this Structure==
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==Solution structure of the PDZ domain of RGS3==
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1WHD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1WHD OCA].
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<StructureSection load='1whd' size='340' side='right'caption='[[1whd]]' scene=''>
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[[Category: Mus musculus]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[1whd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WHD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WHD FirstGlance]. <br>
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[[Category: Inoue, M.]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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[[Category: Kigawa, T.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1whd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1whd OCA], [https://pdbe.org/1whd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1whd RCSB], [https://www.ebi.ac.uk/pdbsum/1whd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1whd ProSAT], [https://www.topsan.org/Proteins/RSGI/1whd TOPSAN]</span></td></tr>
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[[Category: Koshiba, S.]]
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</table>
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[[Category: Nakanishi, T.]]
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== Function ==
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[[Category: Nemoto, N.]]
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[https://www.uniprot.org/uniprot/RGS3_MOUSE RGS3_MOUSE] Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases.<ref>PMID:11301003</ref> <ref>PMID:12210723</ref>
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[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
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== Evolutionary Conservation ==
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[[Category: Yokoyama, S.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: pdz domain]]
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Check<jmol>
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[[Category: regulator of g-protein signaling]]
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<jmolCheckbox>
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[[Category: riken structural genomics/proteomics initiative]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wh/1whd_consurf.spt"</scriptWhenChecked>
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[[Category: rsgi]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: structural genomics]]
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1whd ConSurf].
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<div style="clear:both"></div>
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 05:25:10 2007''
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==See Also==
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*[[Regulator of G-protein signaling 3D structures|Regulator of G-protein signaling 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Inoue M]]
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[[Category: Kigawa T]]
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[[Category: Koshiba S]]
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[[Category: Nakanishi T]]
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[[Category: Nemoto N]]
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[[Category: Yokoyama S]]

Current revision

Solution structure of the PDZ domain of RGS3

PDB ID 1whd

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