1whv

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(New page: 200px<br /><applet load="1whv" size="450" color="white" frame="true" align="right" spinBox="true" caption="1whv" /> '''Solution structure of the RNA binding domain...)
Current revision (13:40, 9 May 2024) (edit) (undo)
 
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[[Image:1whv.jpg|left|200px]]<br /><applet load="1whv" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1whv" />
 
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'''Solution structure of the RNA binding domain from hypothetical protein BAB23382'''<br />
 
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==About this Structure==
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==Solution structure of the RNA binding domain from hypothetical protein BAB23382==
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1WHV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1WHV OCA].
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<StructureSection load='1whv' size='340' side='right'caption='[[1whv]]' scene=''>
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[[Category: Mus musculus]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[1whv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WHV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WHV FirstGlance]. <br>
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[[Category: Inoue, M.]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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[[Category: Kigawa, T.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1whv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1whv OCA], [https://pdbe.org/1whv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1whv RCSB], [https://www.ebi.ac.uk/pdbsum/1whv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1whv ProSAT], [https://www.topsan.org/Proteins/RSGI/1whv TOPSAN]</span></td></tr>
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[[Category: Muto, Y.]]
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</table>
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[[Category: Nagata, T.]]
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== Function ==
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[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
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[https://www.uniprot.org/uniprot/PARN_MOUSE PARN_MOUSE] 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization (By similarity).
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[[Category: Shirouzu, M.]]
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== Evolutionary Conservation ==
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[[Category: Terada, T.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Yokoyama, S.]]
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Check<jmol>
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[[Category: parn]]
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<jmolCheckbox>
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[[Category: poly(a)-specific ribonuclease]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wh/1whv_consurf.spt"</scriptWhenChecked>
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[[Category: rbd]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: riken structural genomics/proteomics initiative]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: rna binding domain]]
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</jmolCheckbox>
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[[Category: rna recognition motif]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1whv ConSurf].
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[[Category: rnp]]
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<div style="clear:both"></div>
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[[Category: rrm]]
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[[Category: rsgi]]
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[[Category: structural genomics]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 05:26:07 2007''
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==See Also==
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*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Inoue M]]
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[[Category: Kigawa T]]
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[[Category: Muto Y]]
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[[Category: Nagata T]]
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[[Category: Shirouzu M]]
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[[Category: Terada T]]
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[[Category: Yokoyama S]]

Current revision

Solution structure of the RNA binding domain from hypothetical protein BAB23382

PDB ID 1whv

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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