3e3u

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{{Seed}}
 
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[[Image:3e3u.jpg|left|200px]]
 
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==Crystal structure of Mycobacterium tuberculosis peptide deformylase in complex with inhibitor==
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The line below this paragraph, containing "STRUCTURE_3e3u", creates the "Structure Box" on the page.
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<StructureSection load='3e3u' size='340' side='right'caption='[[3e3u]], [[Resolution|resolution]] 1.56&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3e3u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E3U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E3U FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.56&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=NVC:N-[(2R)-2-{[(2S)-2-(1,3-BENZOXAZOL-2-YL)PYRROLIDIN-1-YL]CARBONYL}HEXYL]-N-HYDROXYFORMAMIDE'>NVC</scene></td></tr>
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{{STRUCTURE_3e3u| PDB=3e3u | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e3u OCA], [https://pdbe.org/3e3u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e3u RCSB], [https://www.ebi.ac.uk/pdbsum/3e3u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e3u ProSAT]</span></td></tr>
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</table>
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===Crystal structure of Mycobacterium tuberculosis peptide deformylase in complex with inhibitor===
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== Function ==
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[https://www.uniprot.org/uniprot/DEF_MYCTU DEF_MYCTU] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 19008098 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e3/3e3u_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_19008098}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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3E3U is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E3U OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e3u ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:19008098</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: Peptide deformylase]]
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[[Category: Koehn J]]
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[[Category: Koehn, J.]]
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[[Category: Meng W]]
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[[Category: Meng, W.]]
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[[Category: Pan S]]
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[[Category: Pan, S.]]
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[[Category: Xu M]]
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[[Category: Xu, M.]]
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[[Category: Hydrolase]]
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[[Category: Iron]]
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[[Category: Metal-binding]]
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[[Category: Metallo-enzyme]]
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[[Category: Protein biosynthesis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 21 10:45:31 2009''
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Current revision

Crystal structure of Mycobacterium tuberculosis peptide deformylase in complex with inhibitor

PDB ID 3e3u

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