3fcu

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{{Seed}}
 
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[[Image:3fcu.jpg|left|200px]]
 
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==Structure of headpiece of integrin aIIBb3 in open conformation==
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The line below this paragraph, containing "STRUCTURE_3fcu", creates the "Structure Box" on the page.
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<StructureSection load='3fcu' size='340' side='right'caption='[[3fcu]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3fcu]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FCU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FCU FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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{{STRUCTURE_3fcu| PDB=3fcu | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fcu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fcu OCA], [https://pdbe.org/3fcu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fcu RCSB], [https://www.ebi.ac.uk/pdbsum/3fcu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fcu ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fc/3fcu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fcu ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The complete ectodomain of integrin alpha(IIb)beta(3) reveals a bent, closed, low-affinity conformation, the beta knee, and a mechanism for linking cytoskeleton attachment to high affinity for ligand. Ca and Mg ions in the recognition site, including the synergistic metal ion binding site (SyMBS), are loaded prior to ligand binding. Electrophilicity of the ligand-binding Mg ion is increased in the open conformation. The beta(3) knee passes between the beta(3)-PSI and alpha(IIb)-knob to bury the lower beta leg in a cleft, from which it is released for extension. Different integrin molecules in crystals and EM reveal breathing that appears on pathway to extension. Tensile force applied to the extended ligand-receptor complex stabilizes the closed, low-affinity conformation. By contrast, an additional lateral force applied to the beta subunit to mimic attachment to moving actin filaments stabilizes the open, high-affinity conformation. This mechanism propagates allostery over long distances and couples cytoskeleton attachment of integrins to their high-affinity state.
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===Structure of headpiece of integrin aIIBb3 in open conformation===
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Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces.,Zhu J, Luo BH, Xiao T, Zhang C, Nishida N, Springer TA Mol Cell. 2008 Dec 26;32(6):849-61. PMID:19111664<ref>PMID:19111664</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3fcu" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_19111664}}, adds the Publication Abstract to the page
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*[[Integrin 3D structures|Integrin 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19111664 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19111664}}
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__TOC__
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</StructureSection>
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==Disease==
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Known disease associated with this structure: Glanzmann thrombasthenia, type A OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=607759 607759]], Thrombocytopenia, neonatal alloimmune OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=607759 607759]]
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==About this Structure==
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3FCU is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FCU OCA].
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==Reference==
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<ref group="xtra">PMID:19111664</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Luo, B H.]]
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[[Category: Large Structures]]
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[[Category: Nishida, N.]]
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[[Category: Luo B-H]]
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[[Category: Springer, T A.]]
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[[Category: Nishida N]]
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[[Category: Xiao, T.]]
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[[Category: Springer TA]]
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[[Category: Zhang, C.]]
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[[Category: Xiao T]]
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[[Category: Zhu, J.]]
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[[Category: Zhang C]]
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[[Category: Allostery]]
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[[Category: Zhu J]]
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[[Category: Alternative splicing]]
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[[Category: Cell adhesion]]
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[[Category: Cell adhesion/blood clotting complex]]
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[[Category: Cell adhesion/immune system complex]]
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[[Category: Crystal structure]]
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[[Category: Disease mutation]]
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[[Category: Fibrinogen binding]]
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[[Category: Glycoprotein]]
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[[Category: Host-virus interaction]]
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[[Category: Integrin]]
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[[Category: Membrane]]
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[[Category: Phosphoprotein]]
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[[Category: Platelet integrin alphaiibbeta3]]
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[[Category: Polymorphism]]
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[[Category: Receptor]]
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[[Category: Therapeutic antagonism]]
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[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 21 10:49:26 2009''
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Current revision

Structure of headpiece of integrin aIIBb3 in open conformation

PDB ID 3fcu

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