3e7g

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{{Seed}}
 
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[[Image:3e7g.png|left|200px]]
 
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==Structure of human INOSOX with inhibitor AR-C95791==
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The line below this paragraph, containing "STRUCTURE_3e7g", creates the "Structure Box" on the page.
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<StructureSection load='3e7g' size='340' side='right'caption='[[3e7g]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3e7g]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E7G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E7G FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AT2:ETHYL+4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE'>AT2</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3e7g| PDB=3e7g | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e7g OCA], [https://pdbe.org/3e7g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e7g RCSB], [https://www.ebi.ac.uk/pdbsum/3e7g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e7g ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NOS2_HUMAN NOS2_HUMAN] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e7/3e7g_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e7g ConSurf].
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<div style="clear:both"></div>
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===Structure of human INOSOX with inhibitor AR-C95791===
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==See Also==
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*[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]]
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__TOC__
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 18849972 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18849972}}
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==About this Structure==
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3E7G is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E7G OCA].
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==Reference==
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Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase., Garcin ED, Arvai AS, Rosenfeld RJ, Kroeger MD, Crane BR, Andersson G, Andrews G, Hamley PJ, Mallinder PR, Nicholls DJ, St-Gallay SA, Tinker AC, Gensmantel NP, Mete A, Cheshire DR, Connolly S, Stuehr DJ, Aberg A, Wallace AV, Tainer JA, Getzoff ED, Nat Chem Biol. 2008 Nov;4(11):700-7. Epub 2008 Oct 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18849972 18849972]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Nitric-oxide synthase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Aberg A]]
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[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
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[[Category: Andersson G]]
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[[Category: Alternative splicing]]
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[[Category: Andrews G]]
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[[Category: Calcium]]
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[[Category: Arvai AS]]
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[[Category: Calmodulin-binding]]
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[[Category: Cheshire DR]]
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[[Category: Fad]]
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[[Category: Connolly S]]
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[[Category: Fmn]]
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[[Category: Crane BR]]
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[[Category: Heme]]
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[[Category: Garcin ED]]
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[[Category: Iron]]
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[[Category: Gensmantel NP]]
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[[Category: Metal-binding]]
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[[Category: Getzoff ED]]
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[[Category: Nadp]]
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[[Category: Hamley PJ]]
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[[Category: Nitric oxide]]
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[[Category: Kroeger MD]]
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[[Category: No]]
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[[Category: Mallinder PR]]
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[[Category: Oxidoreductase]]
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[[Category: Mete A]]
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[[Category: Phosphoprotein]]
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[[Category: Nicholls DJ]]
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[[Category: Polymorphism]]
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[[Category: Rosenfeld RJ]]
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[[Category: Tetrahydrobiopterin]]
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[[Category: St-Gallay SA]]
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[[Category: Zinc]]
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[[Category: Stueh DJ]]
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[[Category: Tainer JA]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 21 20:35:02 2009''
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[[Category: Tinker AC]]
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[[Category: Wallace AV]]

Current revision

Structure of human INOSOX with inhibitor AR-C95791

PDB ID 3e7g

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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