3e67

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:44, 21 February 2024) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:3e67.png|left|200px]]
 
-
<!--
+
==Murine inos dimer with inhibitor 4-MAP bound==
-
The line below this paragraph, containing "STRUCTURE_3e67", creates the "Structure Box" on the page.
+
<StructureSection load='3e67' size='340' side='right'caption='[[3e67]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3e67]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E67 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E67 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BVF:4-METHYLPYRIDIN-2-AMINE'>BVF</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-
{{STRUCTURE_3e67| PDB=3e67 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e67 OCA], [https://pdbe.org/3e67 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e67 RCSB], [https://www.ebi.ac.uk/pdbsum/3e67 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e67 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.<ref>PMID:16373578</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e6/3e67_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e67 ConSurf].
 +
<div style="clear:both"></div>
-
===Murine inos dimer with inhibitor 4-MAP bound===
+
==See Also==
-
 
+
*[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]]
-
 
+
== References ==
-
<!--
+
<references/>
-
The line below this paragraph, {{ABSTRACT_PUBMED_18849972}}, adds the Publication Abstract to the page
+
__TOC__
-
(as it appears on PubMed at http://www.pubmed.gov), where 18849972 is the PubMed ID number.
+
</StructureSection>
-
-->
+
[[Category: Large Structures]]
-
{{ABSTRACT_PUBMED_18849972}}
+
-
 
+
-
==About this Structure==
+
-
3E67 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E67 OCA].
+
-
 
+
-
==Reference==
+
-
Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase., Garcin ED, Arvai AS, Rosenfeld RJ, Kroeger MD, Crane BR, Andersson G, Andrews G, Hamley PJ, Mallinder PR, Nicholls DJ, St-Gallay SA, Tinker AC, Gensmantel NP, Mete A, Cheshire DR, Connolly S, Stuehr DJ, Aberg A, Wallace AV, Tainer JA, Getzoff ED, Nat Chem Biol. 2008 Nov;4(11):700-7. Epub 2008 Oct 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18849972 18849972]
+
[[Category: Mus musculus]]
[[Category: Mus musculus]]
-
[[Category: Nitric-oxide synthase]]
+
[[Category: Aberg A]]
-
[[Category: Single protein]]
+
[[Category: Andersson G]]
-
[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
+
[[Category: Andrews G]]
-
[[Category: Calmodulin-binding]]
+
[[Category: Arvai AS]]
-
[[Category: Dimer]]
+
[[Category: Cheshire DR]]
-
[[Category: Fad]]
+
[[Category: Connolly S]]
-
[[Category: Fmn]]
+
[[Category: Crane BR]]
-
[[Category: Heme]]
+
[[Category: Garcin ED]]
-
[[Category: Iron]]
+
[[Category: Gensmantel NP]]
-
[[Category: Isozyme-specific inhibitor]]
+
[[Category: Getzoff ED]]
-
[[Category: Metal-binding]]
+
[[Category: Hamley PJ]]
-
[[Category: Nadp]]
+
[[Category: Kroeger MD]]
-
[[Category: Nitric oxide sythase]]
+
[[Category: Mallinder PR]]
-
[[Category: Oxidoreductase]]
+
[[Category: Mete A]]
-
[[Category: Oxygenase domain]]
+
[[Category: Nicholls DJ]]
-
[[Category: Polymorphism]]
+
[[Category: Rosenfeld RJ]]
-
[[Category: Zinc]]
+
[[Category: St-Gallay SA]]
-
 
+
[[Category: Stueh DJ]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 21 20:42:03 2009''
+
[[Category: Tainer JA]]
 +
[[Category: Tinker AC]]
 +
[[Category: Wallace AV]]

Current revision

Murine inos dimer with inhibitor 4-MAP bound

PDB ID 3e67

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3e67"
Personal tools