2k4b

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{{Seed}}
 
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[[Image:2k4b.jpg|left|200px]]
 
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==CopR Repressor Structure==
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The line below this paragraph, containing "STRUCTURE_2k4b", creates the "Structure Box" on the page.
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<StructureSection load='2k4b' size='340' side='right'caption='[[2k4b]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2k4b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactococcus_lactis_subsp._lactis Lactococcus lactis subsp. lactis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K4B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K4B FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k4b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k4b OCA], [https://pdbe.org/2k4b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k4b RCSB], [https://www.ebi.ac.uk/pdbsum/2k4b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k4b ProSAT]</span></td></tr>
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{{STRUCTURE_2k4b| PDB=2k4b | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9CHA6_LACLA Q9CHA6_LACLA]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k4/2k4b_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k4b ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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CopR of Lactococcus lactis is a copper-responsive repressor involved in copper homoeostasis. It controls the expression of a total of 11 genes, the CopR regulon, in a copper-dependent manner. In the absence of copper, CopR binds to the promoters of the CopR regulon. Copper releases CopR from the promoters, allowing transcription of the downstream genes to proceed. CopR binds through its N-terminal domain to a 'cop box' of consensus TACANNTGTA, which is conserved in Firmicutes. We have solved the NMR solution structure of the N-terminal DNA-binding domain of CopR. The protein fold has a winged helix structure resembling that of the BlaI repressor which regulates antibiotic resistance in Bacillus licheniformis. CopR differs from other copper-responsive repressors, and the present structure represents a novel family of copper regulators, which we propose to call the CopY family.
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===CopR Repressor Structure===
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The copper-responsive repressor CopR of Lactococcus lactis is a 'winged helix' protein.,Cantini F, Banci L, Solioz M Biochem J. 2009 Jan 15;417(2):493-9. PMID:18837698<ref>PMID:18837698</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_18837698}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2k4b" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 18837698 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18837698}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2K4B is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Lactococcus_lactis_subsp._lactis Lactococcus lactis subsp. lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K4B OCA].
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==Reference==
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<ref group="xtra">PMID:18837698</ref><references group="xtra"/>
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[[Category: Lactococcus lactis subsp. lactis]]
[[Category: Lactococcus lactis subsp. lactis]]
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[[Category: Banci, L.]]
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[[Category: Large Structures]]
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[[Category: Cantini, F.]]
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[[Category: Banci L]]
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[[Category: Magnani, D.]]
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[[Category: Cantini F]]
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[[Category: Solioz, M.]]
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[[Category: Magnani D]]
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[[Category: Dna binding protein]]
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[[Category: Solioz M]]
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[[Category: Winged helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 28 09:28:13 2009''
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Current revision

CopR Repressor Structure

PDB ID 2k4b

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