2k5u

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{{Seed}}
 
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[[Image:2k5u.jpg|left|200px]]
 
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==Solution structure of myirstoylated yeast ARF1 protein, GDP-bound==
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The line below this paragraph, containing "STRUCTURE_2k5u", creates the "Structure Box" on the page.
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<StructureSection load='2k5u' size='340' side='right'caption='[[2k5u]], [[NMR_Ensembles_of_Models | 16 NMR models]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2k5u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K5U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K5U FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene></td></tr>
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{{STRUCTURE_2k5u| PDB=2k5u | SCENE= }}
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ARF1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k5u OCA], [https://pdbe.org/2k5u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k5u RCSB], [https://www.ebi.ac.uk/pdbsum/2k5u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k5u ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/ARF1_YEAST ARF1_YEAST]] GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Recruits polyadenylate-binding protein PAB1 to COPI vesicles, and this is required for correct localization of the asymmetrically distributed ASH1 mRNA.<ref>PMID:15356266</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k5/2k5u_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k5u ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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ADP-ribosylation factors (ARFs) are small (21 kDa), monomeric GTPases that are important regulators of membrane traffic. When membrane bound, they recruit soluble adaptors to membranes and trigger the assembly of coating complexes involved in cargo selection and vesicular budding. N-myristoylation is a conserved feature of all ARF proteins that is required for its biological functions, although the mechanism(s) by which the myristate acts in ARF functions is not fully understood. Here we present the structure of a myristoylated ARF1 protein, determined by solution NMR methods, and an assessment of the influence of myristoylation on association of ARF1.GDP and ARF1.GTP with lipid bilayers. A model in which myristoylation contributes to both the regulation of guanine nucleotide exchange and stable membrane association is supported.
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===Solution structure of myirstoylated yeast ARF1 protein, GDP-bound===
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Structure and membrane interaction of myristoylated ARF1.,Liu Y, Kahn RA, Prestegard JH Structure. 2009 Jan 14;17(1):79-87. PMID:19141284<ref>PMID:19141284</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_19141284}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2k5u" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19141284 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19141284}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Atcc 18824]]
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2K5U is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K5U OCA].
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[[Category: Large Structures]]
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[[Category: Liu, Y]]
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==Reference==
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[[Category: Prestegard, J]]
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<ref group="xtra">PMID:19141284</ref><references group="xtra"/>
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Liu, Y.]]
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[[Category: Prestegard, J.]]
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[[Category: Arf]]
[[Category: Arf]]
[[Category: Arf1]]
[[Category: Arf1]]
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[[Category: Signaling protein]]
[[Category: Signaling protein]]
[[Category: Transport]]
[[Category: Transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 28 09:33:11 2009''
 

Current revision

Solution structure of myirstoylated yeast ARF1 protein, GDP-bound

PDB ID 2k5u

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