3ckf

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{{Seed}}
 
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[[Image:3ckf.jpg|left|200px]]
 
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==The crystal structure of OspA deletion mutant==
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The line below this paragraph, containing "STRUCTURE_3ckf", creates the "Structure Box" on the page.
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<StructureSection load='3ckf' size='340' side='right'caption='[[3ckf]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ckf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Borreliella_burgdorferi Borreliella burgdorferi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CKF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CKF FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ckf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ckf OCA], [https://pdbe.org/3ckf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ckf RCSB], [https://www.ebi.ac.uk/pdbsum/3ckf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ckf ProSAT]</span></td></tr>
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{{STRUCTURE_3ckf| PDB=3ckf | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q45040_BORBG Q45040_BORBG]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ck/3ckf_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ckf ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Recent studies suggest the dominant role of main-chain H-bond formation in specifying beta-sheet topology. Its essentially sequence-independent nature implies a large degree of freedom in designing beta-sheet-based nanomaterials. Here we show rational design of beta-sheet face inversions by incremental deletions of beta-strands from the single-layer beta-sheet of Borrelia outer surface protein A. We show that a beta-sheet structure can be maintained when a large number of native contacts are removed and that one can design large-scale conformational transitions of a beta-sheet such as face inversion by exploiting the promiscuity of strand-strand interactions. High-resolution X-ray crystal structures confirmed the success of the design and supported the importance of main-chain H-bonds in determining beta-sheet topology. This work suggests a simple but effective strategy for designing and controlling nanomaterials based on beta-rich peptide self-assemblies.
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===The crystal structure of OspA deletion mutant===
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The promiscuity of beta-strand pairing allows for rational design of beta-sheet face inversion.,Makabe K, Koide S J Am Chem Soc. 2008 Nov 5;130(44):14370-1. Epub 2008 Oct 9. PMID:18842042<ref>PMID:18842042</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3ckf" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_18842042}}, adds the Publication Abstract to the page
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*[[Outer surface protein|Outer surface protein]]
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(as it appears on PubMed at http://www.pubmed.gov), where 18842042 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18842042}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Borreliella burgdorferi]]
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3CKF is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Borrelia_burgdorferi Borrelia burgdorferi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CKF OCA].
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[[Category: Large Structures]]
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[[Category: Koide S]]
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==Reference==
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[[Category: Makabe K]]
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<ref group="xtra">PMID:18842042</ref><references group="xtra"/>
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[[Category: Borrelia burgdorferi]]
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[[Category: Koide, S.]]
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[[Category: Makabe, K.]]
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[[Category: Beta-sheet]]
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[[Category: Membrane protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 28 09:47:49 2009''
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Current revision

The crystal structure of OspA deletion mutant

PDB ID 3ckf

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OCA

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