2kdp
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 2kdp is ON HOLD until Paper Publication Authors: He, Y., Imhoff, R., Sahu, A., Radhakrishnan, I. Description: Solution Structure of the SAP30 zinc ...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Solution Structure of the SAP30 zinc finger motif== | |
| + | <StructureSection load='2kdp' size='340' side='right'caption='[[2kdp]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2kdp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KDP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KDP FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kdp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kdp OCA], [https://pdbe.org/2kdp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kdp RCSB], [https://www.ebi.ac.uk/pdbsum/2kdp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kdp ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SAP30_HUMAN SAP30_HUMAN] Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones.<ref>PMID:9651585</ref> [UniProtKB:O88574] | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kd/2kdp_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kdp ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | + | ==See Also== | |
| - | + | *[[Histone deacetylase 3D structures|Histone deacetylase 3D structures]] | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: He Y]] | ||
| + | [[Category: Imhoff R]] | ||
| + | [[Category: Radhakrishnan I]] | ||
| + | [[Category: Sahu A]] | ||
Current revision
Solution Structure of the SAP30 zinc finger motif
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