2zhk

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{{Seed}}
 
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[[Image:2zhk.png|left|200px]]
 
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==Crystal structure of human galectin-9 N-terminal CRD in complex with N-acetyllactosamine dimer (crystal 1)==
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The line below this paragraph, containing "STRUCTURE_2zhk", creates the "Structure Box" on the page.
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<StructureSection load='2zhk' size='340' side='right'caption='[[2zhk]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2zhk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZHK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZHK FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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{{STRUCTURE_2zhk| PDB=2zhk | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zhk OCA], [https://pdbe.org/2zhk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zhk RCSB], [https://www.ebi.ac.uk/pdbsum/2zhk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zhk ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LEG9_HUMAN LEG9_HUMAN] Binds galactosides. Has high affinity for the Forssman pentasaccharide. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. Inhibits cell proliferation. It is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death. Isoform Short acts as an eosinophil chemoattractant.<ref>PMID:16286920</ref> <ref>PMID:18005988</ref> <ref>PMID:18977853</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zh/2zhk_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zhk ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of human galectin-9 N-terminal CRD in complex with N-acetyllactosamine dimer (crystal 1)===
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==See Also==
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*[[Galectin 3D structures|Galectin 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 18977853 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_18977853}}
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==About this Structure==
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2ZHK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZHK OCA].
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==Reference==
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Structural analysis of the recognition mechanism of poly-N-acetyllactosamine by the human galectin-9 N-terminal carbohydrate recognition domain., Nagae M, Nishi N, Murata T, Usui T, Nakamura T, Wakatsuki S, Kato R, Glycobiology. 2009 Feb;19(2):112-7. Epub 2008 Oct 31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18977853 18977853]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
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[[Category: Kato R]]
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[[Category: Alternative splicing]]
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[[Category: Murata T]]
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[[Category: Beta sandwich]]
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[[Category: Nagae M]]
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[[Category: Carbohydrate binding protein]]
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[[Category: Nakamura T]]
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[[Category: Cytoplasm]]
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[[Category: Nishi N]]
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[[Category: Galectin]]
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[[Category: Usui T]]
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[[Category: Polymorphism]]
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[[Category: Wakatsuki S]]
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[[Category: Secreted]]
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[[Category: Sugar binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 4 20:19:33 2009''
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Current revision

Crystal structure of human galectin-9 N-terminal CRD in complex with N-acetyllactosamine dimer (crystal 1)

PDB ID 2zhk

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