2vs6

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{{Seed}}
 
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[[Image:2vs6.png|left|200px]]
 
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==K173A, R174A, K177A-trichosanthin==
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The line below this paragraph, containing "STRUCTURE_2vs6", creates the "Structure Box" on the page.
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<StructureSection load='2vs6' size='340' side='right'caption='[[2vs6]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2vs6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trichosanthes_kirilowii Trichosanthes kirilowii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VS6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VS6 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vs6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vs6 OCA], [https://pdbe.org/2vs6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vs6 RCSB], [https://www.ebi.ac.uk/pdbsum/2vs6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vs6 ProSAT]</span></td></tr>
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{{STRUCTURE_2vs6| PDB=2vs6 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RIPT_TRIKI RIPT_TRIKI] Inactivates eukaryotic 60S ribosomal subunits.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vs/2vs6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vs6 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Ribosome-inactivating proteins (RIPs) inhibit protein synthesis by enzymatically depurinating a specific adenine residue at the sarcin-ricin loop of the 28S rRNA, which thereby prevents the binding of elongation factors to the GTPase activation centre of the ribosome. Here, we present the 2.2 A crystal structure of trichosanthin (TCS) complexed to the peptide SDDDMGFGLFD, which corresponds to the conserved C-terminal elongation factor binding domain of the ribosomal P protein. The N-terminal region of this peptide interacts with Lys173, Arg174 and Lys177 in TCS, while the C-terminal region is inserted into a hydrophobic pocket. The interaction with the P protein contributes to the ribosome-inactivating activity of TCS. This 11-mer C-terminal P peptide can be docked with selected important plant and bacterial RIPs, indicating that a similar interaction may also occur with other RIPs.
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===K173A, R174A, K177A-TRICHOSANTHIN===
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The C-terminal fragment of the ribosomal P protein complexed to trichosanthin reveals the interaction between the ribosome-inactivating protein and the ribosome.,Too PH, Ma MK, Mak AN, Wong YT, Tung CK, Zhu G, Au SW, Wong KB, Shaw PC Nucleic Acids Res. 2009 Feb;37(2):602-10. Epub 2008 Dec 10. PMID:19073700<ref>PMID:19073700</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2vs6" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_19073700}}, adds the Publication Abstract to the page
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*[[Ribosome inactivating protein 3D structures|Ribosome inactivating protein 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19073700 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19073700}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2VS6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Trichosanthes_kirilowii Trichosanthes kirilowii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VS6 OCA].
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==Reference==
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The C-terminal fragment of the ribosomal P protein complexed to trichosanthin reveals the interaction between the ribosome-inactivating protein and the ribosome., Too PH, Ma MK, Mak AN, Wong YT, Tung CK, Zhu G, Au SW, Wong KB, Shaw PC, Nucleic Acids Res. 2008 Dec 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/19073700 19073700]
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[[Category: Single protein]]
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[[Category: Trichosanthes kirilowii]]
[[Category: Trichosanthes kirilowii]]
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[[Category: RRNA N-glycosylase]]
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[[Category: Au SW]]
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[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
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[[Category: Ma MK]]
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[[Category: Antiviral protein]]
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[[Category: Mak AN]]
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[[Category: Hydrolase]]
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[[Category: Ng A]]
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[[Category: Plant defense]]
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[[Category: Shaw PC]]
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[[Category: Protein synthesis inhibitor]]
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[[Category: Too PH]]
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[[Category: Tc]]
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[[Category: Tung CK]]
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[[Category: Toxin]]
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[[Category: Wong KB]]
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[[Category: Zhu G]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 9 20:09:51 2009''
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Current revision

K173A, R174A, K177A-trichosanthin

PDB ID 2vs6

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